Tuesday 16 August 2022 - 04:13
In Business 42 Years - Since 1980
PLEASE NOTE: During August 2022 we are doing a comprehensive revision of our customer service workflow. This includes training of current and new personnel. We are expecting that these changes will have only very minimal effects on our overall order processing and shipping activities. However, we do ask any customers who prefer that their shipments go out on Fridays to contact our Customer Service group and let them know about your preferences in advance. Thank you.
Reminder: Genuine LC Laboratories® brand PMA, which we have been manufacturing in the U.S. for more
than 40 years, is available directly from us: Cat No. P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%.
Our PMA is also available from our >50 U.S. and international distributors, and from more than a dozen
major biochemical reagent "resellers" (who sell our PMA under their own brand names and labels)
FREE SHIPPING TO THE U.S. AND 32 OTHER COUNTRIES! [Read more].
T-7887 Torin 1, Free Base, >99%
Synonyms : [mTOR Inhibitor XI]
- Size
- US $
- €
- £
- ¥
- 10 mg
- 98
- 96
- 81
- 13,000
- In stock
- 25 mg
- 213
- 208
- 176
- 28,300
- In stock
- 50 mg
- 340
- 333
- 281
- 45,100
- In stock
- 100 mg
- 569
- 557
- 470
- 75,500
- In stock
- 200 mg
- 866
- 848
- 716
- 114,900
- In stock
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
- M.W. 607.62
- C35H28F3N5O2
- [1222998-36-8]
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A.
- Torin1 is a highly potent and selective ATP-competitive mammalian target of rapamycin (mTOR) kinase inhibitor that directly inhibited both complexes, mTORC1 and mTORC2, with IC50 values between 2 and 10 nM in in vitro kinase assays. It prevented cell growth and proliferation to a far greater degree than rapamycin (please see Cat. No. R-5000, Rapamycin). However, these effects were independent of mTORC2 inhibition and were instead dependent on inhibition of rapamycin-resistant functions of mTORC1 that were necessary for cap-dependent translation and suppression of autophagy. These effects were at least partly mediated through mTORC1-dependent and rapamycin-resistant phosphorylation of 4E-BP1. Thoreen, C.C., et al. "An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1." J. Biol. Chem. 284: 8023-8032 (2009).
- Torin 1 and Torin 2 are potent antimalarials. Hanson, K.K., et al. "Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins." Proc. Natl. Acad. Sci. USA 110: E2838-E2847 (2013).
- Genetic and biochemical evidence obtained using rapamycin or torin 1 and Rheb (Ras homolog enriched in brain) demonstrated that pUL38 prevented endoplasmic reticulum stress-induced cell death independently of its role in mTORC1 activation. Qian, Z., et al. "The human cytomegalovirus protein pUL38 suppresses endoplasmic reticulum stress-mediated cell death independently of its ability to induce mTORC1 activation." J. Virol. 85: 9103-9113 (2011).
- Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.
- This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.
- Not available in some countries; not available to some institutions; not available for some uses.
