Tuesday 16 August 2022 - 03:10
In Business 42 Years - Since 1980
PLEASE NOTE: During August 2022 we are doing a comprehensive revision of our customer service workflow. This includes training of current and new personnel. We are expecting that these changes will have only very minimal effects on our overall order processing and shipping activities. However, we do ask any customers who prefer that their shipments go out on Fridays to contact our Customer Service group and let them know about your preferences in advance. Thank you.
Reminder: Genuine LC Laboratories® brand PMA, which we have been manufacturing in the U.S. for more
than 40 years, is available directly from us: Cat No. P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%.
Our PMA is also available from our >50 U.S. and international distributors, and from more than a dozen
major biochemical reagent "resellers" (who sell our PMA under their own brand names and labels)
FREE SHIPPING TO THE U.S. AND 32 OTHER COUNTRIES! [Read more].
S-9344 Stauprimide, >99%
Synonyms : [N-Benzoyl-7-oxostaurosporine]
- Size
- US $
- €
- £
- ¥
- 1 mg
- 39
- 38
- 32
- 5,200
- In stock
- 5 mg
- 174
- 170
- 143
- 23,100
- In stock
- 10 mg
- 281
- 275
- 232
- 37,300
- In stock
- 25 mg
- 544
- 533
- 449
- 72,200
- In stock
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
- M.W. 584.62
- C35H28N4O5
- [154589-96-5]
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.
- Stauprimide increases the efficiency of directed differentiation of mouse and human embryonic stem cells (ESCs). Stauprimide binds to NME2 and inhibits its nuclear localization, thus leading to downregulation of c-Myc. Zhu, S., et al. "A small molecule primes embryonic stem cells for differentiation." Cell Stem Cell 4: 416-426 (2009).
- Stauprimide interacts with NME2, a c-Myc-activating transcription factor that is highly expressed in ESCs. Stauprimide treatment inhibits the nuclear localization of NME2 and downregulates c-Myc, enhances ESC exit from the pluripotent state and enables differentiation. Zaret, K. "Using Small Molecules to Great Effect in Stem Cell Differentiation." Cell Stem Cell 4: 373-374 (2009).
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
