Tuesday 16 August 2022 - 02:42
In Business 42 Years - Since 1980
PLEASE NOTE: During August 2022 we are doing a comprehensive revision of our customer service workflow. This includes training of current and new personnel. We are expecting that these changes will have only very minimal effects on our overall order processing and shipping activities. However, we do ask any customers who prefer that their shipments go out on Fridays to contact our Customer Service group and let them know about your preferences in advance. Thank you.
Reminder: Genuine LC Laboratories® brand PMA, which we have been manufacturing in the U.S. for more
than 40 years, is available directly from us: Cat No. P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%.
Our PMA is also available from our >50 U.S. and international distributors, and from more than a dozen
major biochemical reagent "resellers" (who sell our PMA under their own brand names and labels)
FREE SHIPPING TO THE U.S. AND 32 OTHER COUNTRIES! [Read more].
S-1700 SB 202190, Free Base, >99%
Synonyms : [FHPI]
- Size
- US $
- €
- £
- ¥
- 25 mg
- 32
- 31
- 26
- 4,200
- In stock
- 50 mg
- 46
- 45
- 38
- 6,100
- In stock
- 100 mg
- 89
- 87
- 73
- 11,800
- In stock
- 200 mg
- 169
- 165
- 139
- 22,400
- In stock
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
- M.W. 331.34
- C20H14FN3O
- [152121-30-7]
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A.
- SB202190, a pyridinyl imidazole, inhibits p38 kinase activity in vivo through competition with ATP. Young, P.R., et al. "Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site." J. Biol. Chem. 272: 12116-12121 (1997).
- Induces apoptosis through activation of cysteine protease (CPP32)-like caspases . Nemoto, S., et al. "Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase." J Biol Chem. 273: 16415-16420 (1998).
- Blocks both lipopolysaccharide (LPS)-induced gene expression and nitric oxide (NO)-induced stabilization of interleukin (IL)-8 mRNA in monocytes. Manthey, C.L., et al. "SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes." J. Leukoc. Biol. 64: 409-417 (1998). Ma, P., et al. "Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation." J. Leukoc. Biol. 76: 278-287 (2004).
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
