S-1700 SB 202190, Free Base, >99%

Synonyms : [FHPI]

  • Size
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  • 25 mg
  • 32
  • 30
  • 26
  • 4,400
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  • In stock
  • 50 mg
  • 46
  • 44
  • 38
  • 6,400
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  • 100 mg
  • 89
  • 85
  • 74
  • 12,300
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  • 200 mg
  • 169
  • 162
  • 140
  • 23,400
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  • M.W. 331.34
  • C20H14FN3O
  • [152121-30-7]

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A.

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  • SB202190, a pyridinyl imidazole, inhibits p38 kinase activity in vivo through competition with ATP. Young, P.R., et al. "Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site." J. Biol. Chem. 272: 12116-12121 (1997).
  • Induces apoptosis through activation of cysteine protease (CPP32)-like caspases . Nemoto, S., et al. "Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase." J Biol Chem. 273: 16415-16420 (1998).
  • Blocks both lipopolysaccharide (LPS)-induced gene expression and nitric oxide (NO)-induced stabilization of interleukin (IL)-8 mRNA in monocytes. Manthey, C.L., et al. "SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes." J. Leukoc. Biol. 64: 409-417 (1998). Ma, P., et al. "Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation." J. Leukoc. Biol. 76: 278-287 (2004).
  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
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