Tuesday 16 August 2022 - 03:31
In Business 42 Years - Since 1980
PLEASE NOTE: During August 2022 we are doing a comprehensive revision of our customer service workflow. This includes training of current and new personnel. We are expecting that these changes will have only very minimal effects on our overall order processing and shipping activities. However, we do ask any customers who prefer that their shipments go out on Fridays to contact our Customer Service group and let them know about your preferences in advance. Thank you.
Reminder: Genuine LC Laboratories® brand PMA, which we have been manufacturing in the U.S. for more
than 40 years, is available directly from us: Cat No. P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%.
Our PMA is also available from our >50 U.S. and international distributors, and from more than a dozen
major biochemical reagent "resellers" (who sell our PMA under their own brand names and labels)
FREE SHIPPING TO THE U.S. AND 32 OTHER COUNTRIES! [Read more].
P-9600 Paclitaxel, >99.5%
Related Terms : [Taxol] [Abraxane]
- Size
- US $
- €
- £
- ¥
- 100 mg
- 35
- 34
- 28
- 4,600
- Add to Cart
- Out of stock
- 250 mg
- 63
- 61
- 52
- 8,400
- Add to Cart
- Out of stock
- 500 mg
- 86
- 84
- 71
- 11,400
- Add to Cart
- Out of stock
- 1 g
- 153
- 149
- 126
- 20,300
- Add to Cart
- Out of stock
- 2 g
- 273
- 267
- 225
- 36,200
- Add to Cart
- Out of stock
- 5 g
- 620
- 607
- 512
- 82,300
- Add to Cart
- Out of stock
- 10 g
- 1,110
- 1,087
- 917
- 147,300
- Add to Cart
- Out of stock
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
- M.W. 853.91
- C47H51NO14
- [33069-62-4]
- M.I. 12: 7117
- M.I. 14: 6982
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 200 mg/mL; soluble in ethanol at 40 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.
- More than 1,250 labs worldwide have purchased Paclitaxel from LC Labs (either directly from us or from our many distributors, many of whom resell under their own labels).
- Antitumor and antileukemic agent originally isolated in 1971 from the bark of the yew tree, Taxus brevifolia. Wani, M.C., et al. "Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia." J. Am. Chem. Soc. 93: 2325-2327 (1971). McGuire, W.P., et al. "Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms" Ann. Int. Med. 111: 273-279 (1989).
- Binds to β-tubulin and promotes the assembly of microtubules that resist depolymerization preventing normal cell division. Rowinsky, E.K., et al. "Taxol: a novel investigational antimicrotubule agent." J. Natl. Cancer Inst. 82: 1247-1259 (1990). Parekh, H. and Simpkins, H. "The transport and binding of taxol." Gen. Pharmacol. 29: 167-172 (1997). Jordan, A., et al. "Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle investigational antimicrotubule agent." Med. Res. Rev. 18: 259-296 (1998).
- Paclitaxel is the active ingredient in the drug product sold under the trade names Abraxane® and Taxol®. This drug is currently approved in at least one country for use in patients with advanced carcinoma of the ovary and/or breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy.. NOTE: THE PACLITAXEL SOLD BY LC LABORATORIES FOR RESEARCH IS NOT ABRAXANE® or TAXOL®, AND IS NOT FOR HUMAN USE.
- Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.
- Induces apoptosis through a JNK-dependent pathway in the early phase followed by a JNK-independent pathway that results in Bcl-2 phosphorylation. Wang, T.H., et al. "Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-termnial kinase (JNK)-dependent and -independent pathways in overian cancer cells." J. Biol. Chem. 274: 8208-8216 (1999). Shtil, A.A., et al. "Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells." Oncogene 18: 377-384 (1999). Srivastava, R.K., et al. "Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase." Mol. Cell. Biol. 18: 3509-3517 (1998). Torres, K., and Horwitz, S.B. "Mechanisms of Taxol-induced cell death are concentration dependent." Cancer Res. 58: 3620-3626 (1998).
