Tuesday 16 August 2022 - 03:34
In Business 42 Years - Since 1980
PLEASE NOTE: During August 2022 we are doing a comprehensive revision of our customer service workflow. This includes training of current and new personnel. We are expecting that these changes will have only very minimal effects on our overall order processing and shipping activities. However, we do ask any customers who prefer that their shipments go out on Fridays to contact our Customer Service group and let them know about your preferences in advance. Thank you.
Reminder: Genuine LC Laboratories® brand PMA, which we have been manufacturing in the U.S. for more
than 40 years, is available directly from us: Cat No. P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%.
Our PMA is also available from our >50 U.S. and international distributors, and from more than a dozen
major biochemical reagent "resellers" (who sell our PMA under their own brand names and labels)
FREE SHIPPING TO THE U.S. AND 32 OTHER COUNTRIES! [Read more].
O-2220 Okadaic Acid, Free Acid, >98%
Synonyms : [Halochondrine A]
- Size
- US $
- €
- £
- ¥
- 50 µg
- 55
- 53
- 45
- 7,300
- In stock
- 100 µg
- 98
- 96
- 81
- 13,000
- In stock
- 300 µg
- 270
- 264
- 223
- 35,800
- In stock
- 1 mg
- 698
- 684
- 577
- 92,600
- In stock
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
- M.W. 805.00
- C44H68O13
- [78111-17-8]
- M.I. 12: 6958
- M.I. 14: 6819
Special Hazard: TUMOR PROMOTER - Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.
Warnings: Highly irritant to skin and mucous membranes.
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol.
- More than 1,000 labs worldwide have purchased Okadaic Acid or its salts from LC Labs, either directly from us or from our distributors and resellers (the latter resell under their own labels).
- The ammonium salt (Cat. No. O-6410), sodium salt (Cat. No. O-5857), and potassium salt (Cat. No. O-7519) forms are also available.
- Please see Technical Note #18 for important information about purity and other technical details.
- Potent inhibitor of protein phosphatases, especially the PP-1 and PP-2 classes, in numerous cell types. Cohen, P. et al., "Okadaic acid: a new probe for the study of cellular regulation." Trends Biochem. Sci. 15: 98-102 (1990).
- Non-phorbol type tumor promoter. Suganuma, M. et al., "Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter." Proc. Natl. Acad. Sci. USA 85: 1768-1771 (1988).
- Important Notes on Stability:
- We believe this product and the three okadaic acid salts below, as shipped from our inventory, are the purest and most stable okadaic acid products available anywhere. In contrast, material from other vendors is often degraded and quite impure. Long-term stability of our four okadaic acid products in their unopened ampules is excellent (one year or more).
- All four okadaic acid products must first be dissolved in an organic solvent to prepare stock solutions. The okadaic acid molecule is large and somewhat hydrophobic, and material may not be reliably dissolved out of the ampule with purely aqueous solutions. We understand that some practitioners use mixed aqueous/organic solvents to dissolve material out of the ampules, but we have not tested the efficacy of this approach ourselves.
- Solutions of the free acid form of okadaic acid in organic solvents are distinctly less stable, even in the freezer, than those made from the three salt forms listed on this web site.
- Once diluted into aqueous media (and assuming equal starting purities), the information available to us indicates that all four forms of okadaic acid show comparable stability.
- The biological activity of all four products is identical for the okadaic acid portion, but obviously the counter-ions themselves may affect ion-sensitive experimental systems.
- In summary, ignoring the counter-ions, all four forms of okadaic acid are biologically equivalent and equally useful if made up as a stock solution in an organic solvent and used within a fews days. If freezer storage of an organic solvent-based stock solution of okadaic acid is anticipated to extend beyond a week or so, we recommend a salt form rather than the free acid.
- Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
