O-2220 Okadaic Acid, Free Acid, >98%

Special Hazard: TUMOR PROMOTER - Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.

Warnings: Highly irritant to skin and mucous membranes.

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol.

EQ-147 EQ-145 EQ-144 EQ-142 EQ-141 EQ-140 EQ-139 EQ-138 EQ-137 EQ-136

View the SDS for this product

• July 31, 2023:  in early July we finished a relatively large new lot of bulk O-2220 Okadaic Acid, Free Acid.  However, for the past three weeks all of our lab personnel have been out of the U.S. or were not at work because of health problems. 
            Those unavoidable absences delayed the preparation of the ammonium, sodium and potassium salts and subdivision of all four OA products into final-sale-size vials to fill backorders and new orders.
            We expect that our returning lab workers will be able to fill and ship all backorders for OA and its salts by Friday, August 4.   We apologize very much for these delays.
  
  
  
• More than 1,000 labs worldwide have purchased Okadaic Acid or its salts from LC Labs, either directly from us or from our distributors and resellers (the latter resell under their own labels).
• The ammonium salt (Cat. No. O-6410), sodium salt (Cat. No. O-5857), and potassium salt (Cat. No. O-7519) forms are also available.
• Please see Technical Note #18 for important information about purity and other technical details.
• Potent inhibitor of protein phosphatases, especially the PP-1 and PP-2 classes, in numerous cell types. Cohen, P. et al., "Okadaic acid: a new probe for the study of cellular regulation." Trends Biochem. Sci. 15: 98-102 (1990).
• Non-phorbol type tumor promoter. Suganuma, M. et al., "Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter." Proc. Natl. Acad. Sci. USA 85: 1768-1771 (1988).
• Important Notes on Stability:
  1. We believe this product and the three okadaic acid salts below, as shipped from our inventory, are the purest and most stable okadaic acid products available anywhere. In contrast, material from other vendors is often degraded and quite impure. Long-term stability of our four okadaic acid products in their unopened ampules is excellent (one year or more).
  2. All four okadaic acid products must first be dissolved in an organic solvent to prepare stock solutions. The okadaic acid molecule is large and somewhat hydrophobic, and material may not be reliably dissolved out of the ampule with purely aqueous solutions. We understand that some practitioners use mixed aqueous/organic solvents to dissolve material out of the ampules, but we have not tested the efficacy of this approach ourselves.
  3. Solutions of the free acid form of okadaic acid in organic solvents are distinctly less stable, even in the freezer, than those made from the three salt forms listed on this web site.
  4. Once diluted into aqueous media (and assuming equal starting purities), the information available to us indicates that all four forms of okadaic acid show comparable stability.
  5. The biological activity of all four products is identical for the okadaic acid portion, but obviously the counter-ions themselves may affect ion-sensitive experimental systems.
  6. In summary, ignoring the counter-ions, all four forms of okadaic acid are biologically equivalent and equally useful if made up as a stock solution in an organic solvent and used within a fews days. If freezer storage of an organic solvent-based stock solution of okadaic acid is anticipated to extend beyond a week or so, we recommend a salt form rather than the free acid.
• Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.