Tuesday 16 August 2022 - 02:41
In Business 42 Years - Since 1980
PLEASE NOTE: During August 2022 we are doing a comprehensive revision of our customer service workflow. This includes training of current and new personnel. We are expecting that these changes will have only very minimal effects on our overall order processing and shipping activities. However, we do ask any customers who prefer that their shipments go out on Fridays to contact our Customer Service group and let them know about your preferences in advance. Thank you.
Reminder: Genuine LC Laboratories® brand PMA, which we have been manufacturing in the U.S. for more
than 40 years, is available directly from us: Cat No. P-1680 Phorbol 12-Myristate 13-Acetate, >99.5%.
Our PMA is also available from our >50 U.S. and international distributors, and from more than a dozen
major biochemical reagent "resellers" (who sell our PMA under their own brand names and labels)
FREE SHIPPING TO THE U.S. AND 32 OTHER COUNTRIES! [Read more].
L-4804 Lapatinib, Di-p-Toluenesulfonate Salt, >99%
Synonyms : [GW-572016] [Lapatinib Ditosylate]
Related Terms : [Tykerb] [Tyverb]
- Size
- US $
- €
- £
- ¥
- 100 mg
- 33
- 32
- 27
- 4,400
- In stock
- 200 mg
- 59
- 57
- 48
- 7,800
- In stock
- 300 mg
- 78
- 76
- 64
- 10,300
- In stock
- 500 mg
- 102
- 99
- 84
- 13,500
- In stock
- 1 g
- 126
- 123
- 104
- 16,700
- In stock
- 2 g
- 228
- 223
- 188
- 30,200
- In stock
- 5 g
- 455
- 445
- 376
- 60,400
- In stock
- 10 g
- 620
- 607
- 512
- 82,300
- In stock
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
- M.W. 925.46
- C29H26ClFN4O4S•2C7H8O3S
- [388082-77-7]
- M.I. 14: 5367
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 200 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.
- More than 720 labs worldwide have purchased Lapatinib or its salt forms from LC Labs (either directly from us or from our many distributors, many of whom resell under their own labels).
- This research compound is the di-p-toluenesulfonate salt form of Lapatinib. Please see the free base form of lapatinib, Cat. No. L-4899, Lapatinib, Free Base, for further technical information.
- This lapatinib product is the di-p-toluenesulfonate Salt, whose CAS number is given above. The CAS number of the free base form of lapatinib is 231277-92-2.
- Lapatinib inhibits both epidermal growth factor receptor (EGFR) and HER2/neu (ErbB-2) tyrosine kinases by binding to the intracellular phosphorylation domain, preventing receptor autophosphorylation. The exact site of binding has currently not been confirmed. It appears to arrest the development of breast cancer in some patients with metastatic, treatment-refractory disease. Burris, H.A. III "Dual Kinase Inhibition in the Treatment of Breast Cancer: Initial Experience with the EGFR/ErbB-2 Inhibitor Lapatinib." Oncologist 9: 10-15 (2004).
- Potent inhibitor of EGFR kinase (Ki = 3 nM), ErbB-2 kinase (Ki = 13 nM), ErbB-4 kinase (Ki = 347 nM). Wood, E.R., et al. "A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib), Relationships among Protein Conformation, Inhibitor Off-Rate, and Receptor Activity in Tumor Cells." Cancer Res. 64: 6652-6659 (2004).
- Lapatinib can restore tamoxifen sensitivity in tamoxifen-resistant, ER-positive breast cancer models. Chu, I., et al. "The Dual ErbB1/ErbB2 Inhibitor, Lapatinib (GW572016), Cooperates with Tamoxifen to Inhibit Both Cell Proliferation- and Estrogen-Dependent Gene Expression in Antiestrogen-Resistant Breast Cancer." Cancer Res. 65: 18-25 (2005).
- Lapatinib Di-p-Toluenesulfonate Salt is the active ingredient in the drug sold under the trade names Tykerb® in the US and Tyverb® in Europe. This drug has been approved in at least one country to treat advanced metastatic breast cancer in conjunction with the chemotherapy drug Xeloda. NOTE: THE LAPATINIB SOLD BY LC LABORATORIES FOR RESEARCH IS NOT TYKERB® OR TYVERB®, AND IS NOT FOR HUMAN USE.
- Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.
- This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.
- Not available in some countries; not available to some institutions; not available for some uses.
