T-7310 Tyrphostin AG 1478, Free Base, >99%

Related Terms : [AG 1478]

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  • 25 mg
  • 71
  • 66
  • 56
  • 8,100
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  • In stock
  • 100 mg
  • 219
  • 206
  • 173
  • 25,100
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  • 500 mg
  • 725
  • 682
  • 575
  • 83,000
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  • 1 g
  • 1,160
  • 1,092
  • 921
  • 132,700
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  • M.W. 315.75
  • C16H14ClN3O2
  • [175178-82-2]

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 50 mg/mL; soluble in ethanol at 25 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A.

  • Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM). Very weak on PDGF receptor and HER2-NEU kinases (IC50 >100 µM). Osherov, N. and Levitzki, A. "Epidermal-growth-factor-dependent activation of the src-family kinases." Eur. J. Biochem. 225: 1047-1053 (1994). Levitzki, A. and Gazit, A. "Tyrosine kinase inhibition: an approach to drug development." Science 267: 1782-1788 (1995).
  • Reversibly inhibits (IC50 = 9.8 µM) the rat brain Kv1.5 potassium channel in vitro in a non-protein-tyrosine-kinase-mediated manner. Choi, B.H., et al. "Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor." Am. J. Physiol. Cell Physiol. 282: C1461-C1468 (2002).
  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
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