S-3400 SB 203580, Free Base, >99%

Related Terms : [4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole]

  • Size
  • US $
  • £
  • ¥
  • 25 mg
  • 55
  • 48
  • 42
  • 5,600
  • Add to Cart Qty:
  • In stock
  • 50 mg
  • 72
  • 64
  • 55
  • 7,300
  • Add to Cart Qty:
  • In stock
  • 100 mg
  • 129
  • 114
  • 99
  • 13,100
  • Add to Cart Qty:
  • In stock
  • 200 mg
  • 228
  • 202
  • 175
  • 23,100
  • Add to Cart Qty:
  • In stock
  • 500 mg
  • 527
  • 469
  • 404
  • 53,400
  • Add to Cart Qty:
  • In stock
  • 1 g
  • 845
  • 752
  • 648
  • 85,700
  • Add to Cart Qty:
  • In stock

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  • M.W. 377.43
  • C21H16FN3OS
  • [152121-47-6]
  • M.I. A

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; soluble in ethanol at 12.5 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubil.

  • More than 1,000 labs worldwide have purchased SB 203580 from LC Labs (either directly from us or from our many distributors, many of whom resell under their own labels).
  • Important, highly specific inhibitor of the kinase known variously as p38, p40, CSBP, or RK. This kinase is a homolog of MAP kinase. Gallagher, T.F., et al. "2,4,5-Triarylimidazole inhibitors of Il-1 biosynthesis." Bioorg. Med. Chem. Lett. 5: 1171-1176 (1995). Cuenda, A., et al. "SB203580 is a specific inhibitor of MAP kinase homologue which is stimulated by cellular stresses and interleukin-1." FEBS Lett.. 364: 229-233 (1995). Hazzalin, C.A., et al. "Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli." Oncogene 15: 2321-2331 (1997).
  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
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