I-5700 Ionomycin, Free Acid, >99%

New
  • Size
  • US $
  • £
  • ¥
  • 1 mg
  • 17
  • 15
  • 13
  • 2,600
  • Add to Cart
  • Out of stock
  • 5 mg
  • 79
  • 72
  • 62
  • 12,000
  • Add to Cart
  • Out of stock
  • 10 mg
  • 146
  • 134
  • 115
  • 22,200
  • Add to Cart
  • Out of stock
  • 25 mg
  • 298
  • 274
  • 236
  • 45,200
  • Add to Cart
  • Out of stock

Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.

To receive a Formal Quotation for catalog sizes of this product and/or any other products, please add them to your shopping cart and click on the “REQUEST A QUOTATION” box.
Click Here to Request a Quotation for Larger Quantities Free Shipping and Handling to the U.S. and 32 Other Countries
  • M.W. 709.00
  • C41H72O9
  • [56092-81-0]

Warnings: Toxic.

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A.

Select Lot Number to view Certificate of Analysis

View the SDS for this product

  • July 27, 2023:  Ionomycin, Free Acid is on long term backorder and has not yet been scheduled in our production queue.
  • Antibiotic that acts as a potent and selective calcium ionophore; more effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5 pH range with the resulting complex exhibiting intense UV absorption. Liu, C. and Hermann T.E. "Characterization of ionomycin as a calcium ionophore." J. Biol. Chem. 253: 5892-5894 (1978). Kauffman, R.F., et al. "Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria." J. Biol. Chem. 255: 2735-2739 (1980).
  • Ionomycin induces apoptosis in immature B cell lines, for example, in Burkitt lymphoma cells, and in cultured embryonic rat cortical neurons. More mature B cell lines do not undergo apoptosis, but are arrested in the G1 phase of the cell cycle. Takei, N. and Endo, Y. "Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons." Brain Res. 652: 65-70 (1994). Aagaard-Tillery, K.M., et al. "Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis." J. Immunol. 155: 3297-3307 (1995).
  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
151