D-3440 17-DMAG, Hydrochloride Salt, >99%

Synonyms : [Alvespimycin]

  • Size
  • US $
  • £
  • ¥
  • 25 mg
  • 42
  • 37
  • 28
  • 4,600
  • Add to Cart Qty:
  • In stock
  • 100 mg
  • 87
  • 78
  • 59
  • 9,600
  • Add to Cart Qty:
  • In stock
  • 250 mg
  • 198
  • 178
  • 135
  • 21,800
  • Add to Cart Qty:
  • In stock
  • 500 mg
  • 262
  • 235
  • 179
  • 28,900
  • Add to Cart Qty:
  • In stock
  • 1 g
  • 475
  • 427
  • 324
  • 52,400
  • Add to Cart Qty:
  • In stock
  • 2 g
  • 825
  • 742
  • 564
  • 90,900
  • Add to Cart Qty:
  • In stock
  • 5 g
  • 1,468
  • 1,321
  • 1,004
  • 161,800
  • Add to Cart Qty:
  • In stock
  • 10 g
  • 2,150
  • 1,935
  • 1,470
  • 237,000
  • Add to Cart Qty:
  • In stock

Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.

To receive a Quotation for catalog sizes of this product and/or any other products, please add them to your shopping cart and click on the “REQUEST A QUOTATION” box.
Click Here to Request a Quotation for Larger Quantities Click Here to see what Shipping and Handling Costs would be to Your Country
  • M.W. 653.21
  • C32H48N4O8•HCl
  • [467214-21-7]

Warnings: Toxic.

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO; soluble up to about 2 mg/mL in water. Disposal: A.

  • Synthetic derivative of geldanamycin, Cat. No. G-4500, and water-soluble analog of 17-AAG, Cat. No. A-6880, demonstrating stability and low in vivo toxicity similar to 17-AAG, but undergoes limited metabolism compared to 17-AAG. Egorin, M.J., et al. "Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats." Cancer Chemother. Pharmacol. 49: 7-19 (2002).
  • Binds specifically to heat shock protein Hsp90 in a manner similar to geldanamycin. Tian, Z.Q., et al. "Synthesis and biological activities of novel 17-aminogeldanamycin derivatives." Bioorg. Med. Chem. 12: 5317-5329 (2004).
  • Inhibits angiogenesis. Kaur, G, et al. "Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator." Clin. Cancer Res. 10: 4813-4821 (2004).
  • Enhances the radiation-induced cell cycle arrest of human solid tumor cell lines both in vitro and in vivo. Bull, E.E., et al. "Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin." Clin. Cancer Res. 10: 8077-8084 (2004).
  • Exhibits potent anti-tumor activity against MDA-MB-231 breast carcinoma cells and HL60-TB leukemia cells both of which are relatively insensitive to 17-AAG. Hollingshead, M., et al. "In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative." Cancer Chemother. Pharmacol. 56: 115-125 (2005).
  • Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
86