A-5959 Azacitidine, Free Base, >99%

AZC-101 AZC-102

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• Azacitidine is a chemical analog of cytidine, a nucleoside found in DNA and RNA. It inhibits DNA methyltransferase and leads to hypomethylation in the promoter region of transcriptionally silenced genes. Azacytidine demonstrated significant cytotoxicity against both conventional therapy-sensitive and therapy-resistant multiple myeloma (MM) cell lines, as well as multidrug-resistant patient-derived MM cells, with IC50 values of approximately 0.8-3 μM. Azacytidine treatment induced DNA double-strand breaks and apoptosis of MM cells. Kiziltepe T., et al. "5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells." Mol. Cancer Ther. 6: 1718-1727 (2007).
• Azacitidine is the active ingredient in the drug product sold under the trade names Mylosar and Vidaza®. This drug is currently approved in at least one country for use in patients with myelodysplastic syndrome. NOTE: THE AZACITIDINE, FREE BASE RESEARCH COMPOUND SOLD BY LC LABORATORIES IS NOT MYLOSAR OR VIDAZA®, AND IS NOT FOR HUMAN USE.
• Related CAS numbers: 879492-75-8 for the methanesulfonate salt; 1401238-96-7 for the sulfate salt; 1401238-97-8 for the hydrobromide salt.
• Other CAS numbers previously assigned to 5-Azacitidine, Free Base, namely 52934-49-3 and 292869-98-8, have been deleted by CAS and are no longer in use.
• Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use
• This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.
• Not available in some countries; not available to some institutions; not available for some uses.