Safety Data Sheet

SECTION 1. IDENTIFICATION:
Trade name: Epothilone B, Free Base
Product Number: E-5500
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420

SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: Toxic
RTECS Substance category: Drug
Harmful if swallowed, inhaled, or absorbed through the skin
Exposure will cause serious damage to the eyes
Exposure may result in mutagenic effects
Exposure may cause congenital malformations in the fetus
Ingestion can cause nausea, vomiting, neutropenia (reduction of a certain type of white blood cells), hyperbilirubinemia (increased levels of bilirubin in the blood), and elevated liver enzymes (ALT/AST)
Signal Word: Danger
GHS Hazard Statements:
H302+312+332 - Harmful if swallowed, in contact with skin or if inhaled
GHS Precautionary Statements:
P2562 - Do not get in eyes, on skin or on clothing
WARNING: For Laboratory Research Use Only
 

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Synonyms: EPO-906, EpoB, Patupilone
Hazardous Ingredient: Epothilone B, Free Base
CAS Registry Number: 152044-54-7
Molecular Weight: 507.68
Molecular Formula: C₂₇H₄₁NO₆S

SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.

SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: handle with Nitrile rubber gloves with minimum thickness of 0.11 mm (4.3 mil). This recommendation should not be interpreted as offering an approval for any specific use conditions. Please review this recommendation with a safety officer to evaluate if it is appropriate for the anticipated use.
Eye protection: chemical safety goggles

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid; granular or powder
Color: white to off-white
Odor: none
Melting point/Melting range: 115-126 ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content:
Organic solvents: soluble in DMSO at 40 mg/mL; soluble in ethanol at 40 mg/mL

SECTION 10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide, and nitrogen oxides

SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: JG6799500
Acute toxicity: intravenous toxicity (TDLo): 1.75 mg/kg (rat), 2-8 mg/kg (mouse); intraperitoneal toxicity (TDLo): 2.4 mg/kg (mouse); intravenous toxicity (TDLo): 2 mg/kg (mouse)
Primary irritant effect:
On the skin: irritant; harmful if absorbed through the skin
On the eye: irritant; harmful in contact with eyes
Inhalation: irritant; harmful if inhaled
Ingestion: harmful if swallowed

SECTION 12. ECOLOGICAL INFORMATION:
General notes: This material may be very toxic to aquatic organisms if it is directly released into the environment

SECTION 13. DISPOSAL CONSIDERATIONS:
Dispose of in accordance with prevailing country, federal, state and local regulations

SECTION 14. TRANSPORT INFORMATION:
UN Number: UN 2811
DOT:
Proper shipping name: Toxic solid, organic, n.o.s. (Epothilone B)
Hazard Class: 6.1
Packing group: II
IATA class:
Proper shipping name: Toxic solid, organic, n.o.s. (Epothilone B)
Hazard Class: 6.1
Packing group: II

SECTION 15. REGULATORY INFORMATION:
Code letter and hazard designation of product:
T: Toxic
EU Risk And Safety phrases:
S22: Do not breathe dust
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
R24/25: Toxic in contact with skin and if swallowed
R37/38: Irritating to respiratory system and skin
R41: Risk of serious damage to eyes
R46: May cause heritable genetic damage
R60: May impair fertility

SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability
Reviewed:  July 1, 2019