Safety Data Sheet

SAFETY DATA SHEET - LC LABORATORIES
REVISION DATE: JULY 1, 2019

SECTION 1. IDENTIFICATION:
Trade name: Celecoxib
Product Number: C-1502
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420


SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: pharmaceutically active substance
Substance Class Identifier: Tumorigen; Drug; Human Data
May be harmful if swallowed, inhaled, or by skin absorption
Ingestion may result in gastrointestinal effects (nausea, abdominal pain, dyspepsia (heartburn), bleeding, ulceration, and perforation), peripheral edema (swelling of face/extremities), hives, urticaria (redness and swelling of the skin), rash, chills, yellowing of skin and eyes, headache, dizziness, vomiting, diarrhea, insomnia, hypertension (increase in blood pressure), respiratory infection, chest pain, myocardial infarction (heart attack), stroke, congestive heart failure, liver effects, kidney effects, changes in blood cell levels, Stevens Johnson Syndrome (life-threatening skin condition), and prolonged bleeding time
Serious allergic reactions, including anaphylaxis, have been reported; individuals with known hypersensitivity or allergic reaction to other NSAID family members or sulfonamides should avoid exposure
May damage fertility or the unborn child; pregnant and nursing women should avoid exposure
Toxic to aquatic life
Exposure may cause irritation of the skin, eyes, and respiratory tract
Signal Word: Danger
GHS Hazard Statements:
H302+312+332 - Harmful if swallowed, in contact with skin or if inhaled
GHS Precautionary Statements:
P2562 - Do not get in eyes, on skin or on clothing
WARNING: For Laboratory Research Use Only

 

SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name:4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-benzenesulfonamide
Synonyms: Celebrex, Celebra, Celecox, Eurocox, Medicoxib, Onsenal, Solexa, SC-58635, Xilebao, YM-177
Hazardous Ingredient: Celecoxib
CAS Registry Number: 169590-42-5
Molecular Weight: 381.37
Molecular Formula: C17H14F3N3O2S


SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician


SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder, or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.


SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13


SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC


SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: handle with Nitrile rubber gloves with minimum thickness of 0.11 mm (4.3 mil). This recommendation should not be interpreted as offering an approval for any specific use conditions. Please review this recommendation with a safety officer to evaluate if it is appropriate for the anticipated use.
Eye protection: chemical safety goggles

 

SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid; granular or powder
Color: white
Odor: none
Melting point/Melting range: 160-162 ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content: none
Organic solvents: soluble in DMSO at 200 mg/mL; soluble in ethanol at 100 mg/mL


SECTION 10. STABILITY AND REACTIVITY:
Stability: stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides


SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: DB2944937
Acute toxicity: subcutaneous toxicity (TDLo): 1 mg/kg (mouse), 263.2-6370 µg/kg (rat); oral toxicity (TDLo): 5-100 mg/kg (mouse); 0.1-100 mg/kg (rat), 5.71 mg/kg (human); intraperitoneal toxicity (TDLo): 20-80 mg/kg (mouse, 1-38 mg/kg (rat)
Primary irritant effect:
On the skin: may be an irritant; may be harmful if absorbed through the skin
On the eye: may be an irritant
Inhalation: may cause respiratory tract irritation; may be harmful if inhaled
Ingestion: may be harmful if swallowed


SECTION 12. ECOLOGICAL INFORMATION:
General notes: toxic to aquatic life
Strictly avoid contamination of the environment


SECTION 13. DISPOSAL CONSIDERATIONS:
Dispose of in accordance with prevailing country, federal, state and local regulations


SECTION 14. TRANSPORT INFORMATION:
UN number: 3077
DOT: Environmentally hazardous substance, solid, n.o.s. (Celecoxib), Class: 9, Packing group: III
IMDG: Environmentally hazardous substance, solid, n.o.s. (Celecoxib), Class: 9, Packing group: III
IATA: Environmentally hazardous substance, solid, n.o.s. (Celecoxib), Class: 9, Packing group: IIII

 

SECTION 15. REGULATORY INFORMATION:
Code letter and hazard designation of product:
Xn: Harmful
EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
R52: Harmful to aquatic organisms
R60: May impair fertility
R61: May cause harm to the unborn child


SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability
Reviewed:  July 1, 2019