Safety Data Sheet

Safety Data Sheet - LC Laboratories
Revision Date: July 1, 2019

SECTION 1. IDENTIFICATION:
Trade name: Vincristine, Sulfate Salt
Product Number: V-8400
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420


SECTION 2. HAZARD(S) IDENTIFICATION:
Hazard Description: Harmful; Irritant
RTECS Substance category: Tumorigen; Drug; Mutagen; Human Data; Reproductive Effector
Harmful if swallowed; may be harmful if inhaled or absorbed through the skin
Irritating to eyes, skin, and respiratory system
Exposure may result in alopecia, constipation, anorexia (loss of appetite), nausea, vomiting, abdominal pain, ileus (obstruction of the small intestine), stomatitis and oral vesiculation (inflammation/blistering/ulceration of the mucous membranes lining of the mouth), pharyngitis, diarrhea, gastrointestinal bleeding, malaise, granulocytopenia (decreased white blood cells), thrombocytopenia (decreased blood platelets), anaemia (decreased red blood cells), hypertension (elevated blood pressure), central and peripheral neurotoxicity, 8th cranial nerve damage resulting in vestibular and auditory toxicity (loss of hearing and balance), ischemic cardiac toxicity, dyspnea (shortness of breath), bone and jaw pain, syndrome of inappropriate antidiuretic hormone resulting in urine retention and hyponatremia (low serum sodium concentration), paresthesias (numbness of fingers), loss of deep tendon reflexes, peripheral neuritis, mental depression, headache, convulsions
Exposure may impair fertility, may cause harm to the unborn and breastfed child, and may cause cancer
Signal Word: Danger
GHS Hazard Statements:
H302+312+332 - Harmful if swallowed, in contact with skin or if inhaled
GHS Precautionary Statements:
P2562 - Do not get in eyes, on skin or on clothing
WARNING: For Laboratory Research Use Only


SECTION 3. COMPOSITION/INFORMATION ON INGREDIENTS:
Chemical Name: 22-Oxovincaleukoblastine sulfate
Synonyms: Kyocristine, LCR sulfate, Leurocristine sulfate, Lilly 37231, Marqib, NSC-67574, Novopharm, Oncovin, Onkovin, 22-Oxovincaleukoblastine sulfate, VCR sulfate, Vincasar PFS, Vincrex, Vincristine hydrogen sulfate, Vincrisul
Hazardous Ingredient: Vincristine, Sulfate Salt
CAS Registry Number: 2068-78-2
Molecular Weight: 923.04
Molecular Formula: C46H56N4O10•H2SO4


SECTION 4. FIRST-AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician


SECTION 5. FIRE-FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.


SECTION 6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13


SECTION 7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC


SECTION 8. EXPOSURE CONTROLS/PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: handle with Nitrile rubber gloves with minimum thickness of 0.11 mm (4.3 mil). This recommendation should not be interpreted as offering an approval for any specific use conditions. Please review this recommendation with a safety officer to evaluate if it is appropriate for the anticipated use.
Eye protection: chemical safety goggles


SECTION 9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid; granular or powder
Color: white
Odor:
Melting point/Melting range: not determined
Danger of explosion: none
Solubility in / Miscibility with water: soluble in water at 25 mg/mL with warming; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content:
Organic solvents: soluble in DMSO at 60 mg/mL; very poorly soluble in ethanol


SECTION 10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide, and nitrogen oxides


SECTION 11. TOXICOLOGICAL INFORMATION:
RTECS #: OH6340000
Acute toxicity: intravenous toxicity (LD50): 1.01 mg/kg (rat), 1.7 mg/kg (mouse); intraperitoneal toxicity (LD50): 1.9 mg/kg (rat), 3 mg/kg (mouse)
Primary irritant effect:
On the skin: causes skin irritation; may be harmful if absorbed through the skin
On the eye: causes eye irritation
Inhalation: causes respiratory tract irritation; may be harmful if inhaled
Ingestion: harmful if swallowed


SECTION 12. ECOLOGICAL INFORMATION:
General notes: no data available
Treat as potentially toxic if released into the environment


SECTION 13. DISPOSAL CONSIDERATIONS:
Dispose of in accordance with prevailing country, federal, state and local regulations


SECTION 14. TRANSPORT INFORMATION:
UN number: 2811
DOT: Toxic solid, organic, n.o.s. (Vincristine Sulfate), Class: 6.1, Packing group: II
IMDG: Toxic solid, organic, n.o.s. (Vincristine Sulfate), Class: 6.1, Packing group: II
IATA: Toxic solid, organic, n.o.s. (Vincristine Sulfate), Class: 6.1, Packing group: II

 

SECTION 15. REGULATORY INFORMATION:
Code letter and hazard designation of product:
Xn: Harmful; Xi: Irritant
EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
R22: Harmful if swallowed
R36/37/38: Irritating to eyes, respiratory system and skin
R46: May cause inheritable genetic damage
R60: May impair fertility
R61: May cause harm to the unborn child


SECTION 16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability
Reviewed:  July 1, 2019