1. IDENTIFICATION OF SUBSTANCE:
Trade name: Leptomycin B
Product Number: L-6100
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420

2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19- [(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6- hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
Synonyms: LMB, Elactocin, CI-940, CL-1957A, NSC-364372, PD-114720
Hazardous Ingredient: Leptomycin B
CAS Registry Number: 87081-35-4
Molecular Weight: 540.73
Molecular Formula: C₃₃H₄₈O₆

3. HAZARDS IDENTIFICATION:
RTECS substance category (refers to ethanol): Tumorigen, Mutagen, Reproductive Effector, Primary Irritant
Exposure may cause irritation to eyes, mucous membranes upper respiratory tract and skin
Exposure may also cause the following; effect fertility and/or newborn and breastfed infants; general anaesthtic, coma,
hallucinations and distorted perceptions; arrythmias; nausea or vomitting
HMIS Ratings: Health =1 Flammability =0 Reactivity =0

4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: may emit toxic fumes under fire conditions

6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: film
Color: clear
Odor:
Melting point/Melting range:
Danger of explosion: none
Solubility in / Miscibility with water: not soluble
Solvent content: none
Organic solvents: soluble in ethanol and methanol

10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide

11. TOXICOLOGICAL INFORMATION:
To the best of our knowledge, the chemical, physical and toxicological properties have not been fully investigated
Only selected Registry of Toxic Effects of Chemical Substances (RTECS) data is presented above
See actual entry in RTECS for complete information
RTECS No: 64-17-5 (Ethanol)
Target Organs: Eyes; Respiratory system; Skin; CNS; Circulatory system; Reproductive system
Toxicity Data: (Data refers to ethanol): RAT-ORL LD50: 7060mg/kg;
RAT-IPR LD50: 3600ug/kg; RAT-IVN LD50: 1440mg/kg;
RAT-IAT LD50: 11mg/kg; MUS-ORL LD50: 3450mg/kg;
IPR-MUS LD50: 528mg/kg; SCU-MUS LD50: 1973mg/kg;
MUS-IVN LD50: 1973mg/kg

12. ECOLOGICAL INFORMATION:
General notes: no data available

13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state and local regulations

14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

15. REGULATIONS:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:
S7: Keep container tightly closed
S9: Keep container in a well ventilated place
S16:Keep away from sources of ignition - no smoking
S24/25: Avoid contact with skin and eyes
S36/37/39: Wear suitable protective clothing, gloves, and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
R11: Highly flammable
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed

16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability for any damage resulting from use of this material.