1. IDENTIFICATION OF SUBSTANCE:
Trade name: Dasatinib
Product Number: D-3307
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420

2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: Dasatinib
Synonyms: BMS-354825, Sprycel
Hazardous Ingredient: Dasatinib
CAS Registry Number: 302962-49-8
Molecular Weight: 488.02
Molecular Formula: C₂₂H₂₆CIN₇O₂S

3. HAZARDS IDENTIFICATION:
Hazard Description: Toxic
May cause serious health effects if swallowed
May be harmful to fetus
Target organs: Gastrointestinal tract, blood, embryo/fetus
May be an irritant; exposure may cause irritation to eyes, skin, mucous membranes, and upper respiratory tract

4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: emits toxic fumes such as carbon monoxide, etc.

6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

7. HANDLING AND STORAGE:
Information for safe handling: avoid inhalation and contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: solid powder
Color: off-white to pale yellow
Odor: none
Melting point/Melting range: 261-285 ºC
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble
Solvent content: none
Organic solvents: very soluble in DMSO, up to about 200 mg/mL; very poorly soluble in ethanol

10. STABILITY AND REACTIVITY:
Stability: stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides

11. TOXICOLOGICAL INFORMATION:
RTECS #:
Acute toxicity: none known
Primary irritant effect:
On the skin: none known
On the eye: not known; may be an irritant

12. ECOLOGICAL INFORMATION:
General notes: no data available

13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state and local regulations

14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

15. REGULATIONS:
Code letter and hazard designation of product:
T: Toxic
EU Risk And Safety phrases:
S22: Do not breathe dust
S29: Do not empty into drains
S36/37/39: Wear suitable protective clothing, gloves, and eye/face protection
S38: In case of insufficient ventilation, wear suitable respiratory equipment
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S53: Avoid exposure - optain special instructions before use
R25: Toxic if swallowed
R48/22: Harmful: danger of serious damge to health by prolonged exposure if swallowed
R61: May cause harm to unborn child

16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability for any damage resulting from use of this material.