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Biological Activity Index

Adenylate Cyclase Activators

F-9929 Forskolin

Alcohol Dehydrogenase Inhibitors

D-2946 Daidzein
D-7878 Daidzin

AMP Protein Kinase (AMPK) Activator

A-1803 A-769662

Anthracycline Antibiotics

D-4000 Doxorubicin, Hydrochloride Salt

Anti-Cancer Compounds

A-6880 17-AAG
A-1040 Ascomycin
A-1107 Axitinib, Free Base
B-2422 Bexarotene, Free Acid
B-1408 Bortezomib, Free Base
B-1788 Bosutinib, Free Base
B-6697 Bryostatin 1
B-3517 Bryostatin 2
C-1201 Canertinib, Dihydrochloride Salt
C-2799 Capecitabine
C-2606 CI-994, Free Base
C-8700 Cyclopamine, Free Base
D----- Dactolisib, Free Base
D-3307 Dasatinib, Free Base
D-3440 17-DMAG, Hydrochloride Salt
D-1000 Docetaxel
D-2744 Doramapimod, Free Base
D-3608 Dovitinib, Free Base
D-4000 Doxorubicin, Hydrochloride Salt
E-3866 Entinostat, Free Base
E-4506 Enzastaurin, Free Base
E-5500 Epothilone B, Free Base
E-4007 Erlotinib, Hydrochloride Salt
E-4040 Everolimus
G-9252 GDC-0941, Free Base
G-4408 Gefitinib, Free Base
G-4500 Geldanamycin
G-4177 Gemcitabine, Hydrochloride Salt
I-5508 Imatinib, Methanesulfonate Salt
I-5900 Ingenol 3-Angelate
I-9077 Intedanib, Free Base
I-4122 Irinotecan, Hydrochloride Salt, Trihydrate
L-4804 Lapatinib, Di-p-Toluenesulfonate Salt
L-4899 Lapatinib, Free Base
L-6307 Lestaurtinib
M-7007 Masitinib, Free Base
M-2433 Mocetinostat, Free Base
N-6404 Neratinib
N-8207 Nilotinib, Free Base
N-4288 NVP-BEZ235, Free Base
O-5679 OSU-03012, Hydrochloride Salt
O-7111 Oxaliplatin
P-9600 Paclitaxel
P-3703 Panobinostat, Free Base
P-6706 Pazopanib, Free Base
P-8499 PD 184352, Free Base
P-9688 PD 325901, Free Base
P-7177 Pemetrexed, Disodium Salt, Heptahydrate
P----- Pictilisib, Free Base
P-6040 Pimecrolimus
P-7600 PKC412
P-7501 PX-866
R-5000 Rapamycin
R-7040 Ridaforolimus
R-1234 Roscovitine
S-8906 Saracatinib, Free Base
S-8599 Sorafenib, Free Base
S-8502 Sorafenib, p-Toluenesulfonate Salt
S-8877 Sunitinib, Free Base
S-8803 Sunitinib, Malate Salt
T----- Tacedinaline, Free Base
T-7802 Tandutinib, Free Base
T-8040 Temsirolimus
V-9402 Vandetanib, Free Base
V-8303 Vatalanib, Dihydrochloride Salt
V-4050 Vismodegib, Free Base
Z-9040 Zotarolimus, Free Base
Z-1066 ZSTK474, Free Base

Anti-Neoplastic Compounds (See Anti-Cancer Compounds)

Apoptosis Reagents

B-8500 Brefeldin A
C-8700 Cyclopamine, Free Base
E-4506 Enzastaurin, Free Base
S-8906 Saracatinib, Free Base

ATPase Inhibitors (See Also Ion-Modulating
Reagents—Ion Co-Transporters)

B-1080 Bafilomycin A1
T-3250 Thapsigargin

Calcineurin (See Protein Phosphatase 2B)

Calcium-Related Reagents

Calcium Releasers (from Intracellular Stores)
T-3250 Thapsigargin

Ion Channel Activators

Calcium/Divalent Cation Channel Activators
R-6712 Resiniferatoxin (RTX)
T-5096 Tinyatoxin (TYX)

TRPV Cation Channel Activators (a.k.a. OTRPCH, VR-OAC, TRP12, VRL-2)
P-2170 4α-Phorbol 12,13-Didecanoate
P-8880 4α-Phorbol 12-Myristate 13-Acetate

Ionophores, Calcium
I-5700 Ionomycin, Free Acid
I-6800 Ionomycin, Calcium Salt

Ion Transporter/Co-transporter Inhibitors (Ca2+)
T-3250 Thapsigargin

Capsaicin-Related Reagents

R-6712 Resiniferatoxin (RTX)
T-5096 Tinyatoxin (TYX)

cdc/cdk Kinases (See Cell Cycle Reagents)

Cell Cycle Reagents

Cyclin/cdc/cdk Kinase Inhibitors
R-1234 Roscovitine, Free Base

CSBP Kinase (See MEK and MEK Kinases)

Cyclic Nucleotide Reagents

See individual entries, e.g. Adenylate Cyclase,
Guanylate Cyclase, Phosphodiesterase, PKA, PKC, PKG

Cyclin/cdc/cdk Kinases (See Cell Cycle Reagents)

EGF Receptor Kinase Inhibitors (See also Tyrosine Kinase Reagents)

T-7310 Tyrphostin AG 1478, Free Base

Endoplasmic Reticulum Reagents

B-8500 Brefeldin A
T-3250 Thapsigargin

Enzyme Activators and Inhibitors — See individual enzyme entries

ERK Kinase (See MEK and MEK Kinases)

FLK-1 (See VEGF Receptor Kinase)

Golgi Reagents

B-8500 Brefeldin A

Heat Shock Protein Modulators

A-6880 17-AAG
D-3440 17-DMAG, Hydrochloride Salt
G-4500 Geldanamycin
P-3703 Panobinostat, Free Base

Hedgehog Inhibitors

Smoothened (Smo) Inhibitors
C-8700 Cyclopamine, Free Base
V-4050 Vismodegib, Free Base

Histamine Secretagogues

T-3250 Thapsigargin

Histone Deacetylase (HDAC) Inhibitors

C-2606 CI-994, Free Base
E-3866 Entinostat, Free Base
M-2433 Mocetinostat, Free Base
P-3703 Panobinostat, Free Base
T----- Tacedinaline, Free Base
V-8477 Vorinostat

Immunosuppressants

A-1040 Ascomycin
C----- CP-690550, Citrate Salt
C-1377 CP-690550, Free Base
C-6000 Cyclosporin A
E-4040 Everolimus
F-4633 Fingolimod, Hydrochloride Salt
F-4900 FK-506
P-6040 Pimecrolimus
R-7040 Ridaforolimus
R-5000 Rapamycin
T-8040 Temsirolimus
T----- Tasocitinib, Citrate Salt
T-1377 Tasocitinib, Free Base
T-1399 Tofacitinib, Citrate Salt
T-1377 Tofacitinib, Free Base
Z-9040 Zotarolimus, Free Base

Ion Channel Reagents

H+-ATPase Inhibitors (See also ATPase Inhibitors)
B-1080 Bafilomycin A1

Calcium Releasers (from Intracellular Stores)
T-3250 Thapsigargin

Ion Channel Activators

Calcium/Divalent Cation Channel Activators
R-6712 Resiniferatoxin (RTX)
T-5096 Tinyatoxin (TYX)

TRPV Cation Channel Activators (a.k.a. OTRPCH, VR-OAC, TRP12, VRL-2)
P-2170 4α-Phorbol 12,13-Didecanoate
P-8880 4α-Phorbol 12-Myristate 13-Acetate

Ionophores, Calcium
I-5700 Ionomycin, Free Acid
I-6800 Ionomycin, Calcium Salt

Ion Transporter/Co-transporter Inhibitors (Ca2+)
T-3250 Thapsigargin

Isoflavones (See Soybean Isoflavones)

JAK-2 Kinase Inhibitors

T-9142 Tyrphostin AG 490

JAK-3 Kinase Inhibitors

C----- CP-690550, Citrate Salt
C-1377 CP-690550, Free Base
C----- CP-690550, Citrate Salt
T----- Tasocitinib, Citrate Salt
T-1377 Tasocitinib, Free Base
T-1399 Tofacitinib, Citrate Salt
T-1377 Tofacitinib, Free Base

Kinase Inhibitors, Non-Selective

P-7600 PKC412
S-9300 Staurosporine, Free Base

MAP Kinases (See MEK and MEK Kinases)

MEK and MEK Kinase Inhibitors

D-2744 Doramapimod, Free Base
P-4313 PD 98059
P-8499 PD 184352, Free Base
P-9688 PD 325901, Free Base
S-1700 SB 202190, Free Base
S-3400 SB 203580, Free Base
U-6770 U0126
V-9366 VX-702, Free Base

mTOR Inhibitors (see under "T")

Myosin Light Chain Kinase Inhibitors

W-2990 Wortmannin

Neurochemicals

R-6712 Resiniferatoxin (RTX)
T-5096 Tinyatoxin (TYX)

Nuclear Export Inhibitors

L-6100 Leptomycin B, Free Acid (LMB)

p38 Kinase (See MEK and MEK Kinases)

p40 Kinase (See MEK and MEK Kinases)

PARP Inhibitors (see Poly(ADP-ribose) Polymerase Inhibitors)

Phosphatidylinositol 3-Kinase Inhibitors

D----- Dactolisib, Free Base
G-9252 GDC-0941, Free Base
L-7962 LY 294002, Free Base
N-4288 NVP-BEZ235, Free Base
P-7050 PIK-75, Hydrochloride Salt
P----- Pictilisib, Free Base
P-7501 PX-866
W-2990 Wortmannin

PI3-Kinase (See Phosphatidylinositol 3-Kinase Inhibitors)

Platinum-based Anti-Cancer Compounds

O-7111 Oxaliplatin

Poly(ADP-ribose) Polymerase (PARP) Inhibitors

O-9201 Olaparib

Proteasome Inhibitors

B-1408 Bortezomib, Free Base

Protein Kinase A (PKA) Inhibitors

F-4660 Fasudil, Monohydrochloride Salt
H-5239 H-89, Dihydrochloride Salt
H-2330 HA-1077, Dihydrochloride Salt
K-2151 K252a
K-9609 K252c
S-9300 Staurosporine, Free Base

Protein Kinase C (PKC)

PKC Activators

PKC-selective but not PKC Isotype-selective Activators
B-6697 Bryostatin 1
B-3517 Bryostatin 2
I-1711 (-)-Indolactam V
I-8560 Ingenol
P-1680 Phorbol 12-Myristate 13-Acetate
P-4462 Prostratin
R-8765 Resiniferonol 9,13,14-Orthophenylacetate

Negative Controls
P-2170 4α-Phorbol 12,13-Didecanoate
P-8880 4α-Phorbol 12-Myristate 13-Acetate

PKC Inhibitors

PKC Isotype-selective Inhibitors
E-4506 Enzastaurin, Free Base
G-6203 Gö 6976
R-9630 Rottlerin - SEE IMPORTANT NOTE!!

PKC Inhibitors not Selective for PKC or of Unknown Selectivity
H-5239 H-89, Dihydrochloride Salt
K-2151 K252a
K-9609 K252c
P-7600 PKC412
S-9300 Staurosporine, Free Base

Protein Kinase G (PKG) Inhibitors

F-4660 Fasudil, Monohydrochloride Salt
H-2330 HA-1077, Dihydrochloride Salt
K-2151 K252a
S-9300 Staurosporine, Free Base

Protein Kinase Inhibitors (see also individual enzymes)

A-1107 Axitinib, Free Base
B-1788 Bosutinib, Free Base
B-1722 Bosutinib Isomer 1, Free Base
C-1201 Canertinib, Dihydrochloride Salt
C----- CP-690550, Citrate Salt
C-1377 CP-690550, Free Base
D-3307 Dasatinib, Free Base
D-3608 Dovitinib, Free Base
E-4506 Enzastaurin, Free Base
E-4007 Erlotinib, Hydrochloride Salt
F-4660 Fasudil, Monohydrochloride Salt
G-9252 GDC-0941, Free Base
G-4408 Gefitinib, Free Base
G-6055 Genistein
G-6203 Gö 6976
G-5903 GW2580, Free Base
H-5239 H-89, Dihydrochloride Salt
H-2330 HA-1077, Dihydrochloride Salt
I-5508 Imatinib, Methanesulfonate Salt
I-9077 Intedanib, Free Base
K-2151 K252a
K-9609 K252c
L-4804 Lapatinib, Di-p-Toluenesulfonate Salt
L-4899 Lapatinib, Free Base
L-6307 Lestaurtinib
L-7962 LY 294002, Free Base
M-7007 Masitinib, Free Base
N-6404 Neratinib
N-8207 Nilotinib, Free Base
O-5679 OSU-03012, Hydrochloride Salt
P-6706 Pazopanib, Free Base
P-4313 PD 98059
P-8499 PD 184352, Free Base
P-9688 PD 325901, Free Base
P-7050 PIK-75, Hydrochloride Salt
P----- Pictilisib, Free Base
P-7600 PKC412
P-7501 PX-866
R-1234 Roscovitine, Free Base
S-8906 Saracatinib, Free Base
S-1700 SB 202190, Free Base
S-3400 SB 203580, Free Base
S-8599 Sorafenib, Free Base
S-8502 Sorafenib, p-Toluenesulfonate Salt
S-7979 SP600125
S-9300 Staurosporine, Free Base
S-8877 Sunitinib, Free Base
S-8803 Sunitinib, Malate Salt
T-7802 Tandutinib, Free Base
T----- Tasocitinib, Citrate Salt
T-1377 Tasocitinib, Free Base
T-1399 Tofacitinib, Citrate Salt
T-1377 Tofacitinib, Free Base
T-9142 Tyrphostin AG 490
T-7310 Tyrphostin AG 1478, Free Base
U-6770 U0126
V-9402 Vandetanib, Free Base
V-8303 Vatalanib, Dihydrochloride Salt
V-9366 VX-702, Free Base
W-2990 Wortmannin
Z-1066 ZSTK474, Free Base

Protein Phosphatase 1 Inhibitors

C-3987 Calyculin A
O-2220 Okadaic Acid, Free Acid
O-7519 Okadaic Acid, Potassium Salt
O-5857 Okadaic Acid, Sodium Salt

Protein Phosphatase 2A Inhibitors

C-3987 Calyculin A
O-2220 Okadaic Acid, Free Acid
O-7519 Okadaic Acid, Potassium Salt
O-5857 Okadaic Acid, Sodium Salt

Protein Phosphatase 2B (Calcineurin) Reagents

Inhibitors
C-6000 Cyclosporin A

Related Reagents
A-1040 Ascomycin
E-4040 Everolimus
F-4900 FK-506
R-5000 Rapamycin
T-8040 Temsirolimus
Z-9040 Zotarolimus, Free Base

Protein Trafficking Reagents

B-8500 Brefeldin A
L-6100 Leptomycin B, Free Acid (LMB)

Retinoid Receptor Modulators

Retinoid X Receptor Modulators
B-2422 Bexarotene, Free Acid

Rho-Associated Kinase II Inhibitors

F-4660 Fasudil, Monohydrochloride Salt
H-2330 HA-1077, Dihydrochloride Salt

RK Kinase (See MEK and MEK Kinases)

Smoothened (Smo) Inhibitors

C-8700 Cyclopamine, Free Base
V-4050 Vismodegib, Free Base

Soybean Isoflavone-Related Compounds

Soybean Constituents
A-6900 6"-O-Acetyldaidzin
A-3000 6"-O-Acetylgenistin
A-7860 6"-O-Acetylglycitin
D-2946 Daidzein
D-7878 Daidzin
G-6055 Genistein
G-5200 Genistin
G-1152 Glycitein
G-2822 Glycitin
M-6730 6"-O-Malonyldaidzin, Free Acid
M-8090 6"-O-Malonylgenistin, Free Acid
M-4620 6"-O-Malonylglycitin, Free Acid

Soybean Isoflavone Metabolites
E-5880 (R,S)-Equol

Sphingolipid Reagents

F-4633 Fingolimod, Hydrochloride Salt

Topoisomerase Inhibitors

I-4122 Irinotecan, Hydrochloride Salt, Trihydrate

mTOR Inhibitors (Mammalian Target of Rapamycin)

E-4040 Everolimus
N-4288 NVP-BEZ235, Free Base
P-6040 Pimecrolimus
R-5000 Rapamycin
R-7040 Ridaforolimus
T-8040 Temsirolimus

Torkinibs - mTOR Kinase Domain Inhibitors

P-6666 PP242

TRPV1 (VR1) Cation Channel Activators

P-6712 Resiniferatoxin
T-5096 Tinyatoxin

TRPV4 Cation Channel Activators (a.k.a. OTRPCH, VR-OAC, TRP12, VRL-2)

P-2170 4α-Phorbol 12,13-Didecanoate
P-8880 4α-Phorbol 12-Myristate 13-Acetate

Tubulin Assembly/Stabilization Promoters

D-1000 Docetaxel
E-5500 Epothilone B, Free Base
P-9600 Paclitaxel

VEGF Receptor Kinase Inhibitors

A-1107 Axitinib, Free Base
I-9077 Intedanib, Free Base
P-6706 Pazopanib, Free Base



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