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Biological Activity Index

Adenylate Cyclase

Activators
F-9929 Forskolin

Anti-Cancer Compounds

A-6880 17-AAG
A-1040 Ascomycin
A-1107 Axitinib, Free Base
B-2422 Bexarotene, Free Acid
B-1408 Bortezomib, Free Base
B-1709 Bosutinib, Free Base
B-6697 Bryostatin 1
B-3517 Bryostatin 2
C-1201 Canertinib, Dihydrochloride Salt
C-2411 Carboplatin
C-3011 Cisplatin
C-8700 Cyclopamine, Free Base
D-3307 Dasatinib, Free Base
D-3440 17-DMAG, Hydrochloride Salt
D-1000 Docetaxel
D-2744 Doramapimod, Free Base
D-3608 Dovitinib, Free Base
E-4111 Eptaplatin
E-4007 Erlotinib, Hydrochloride Salt
E-4040 Everolimus
G-4408 Gefitinib, Free Base
G-4500 Geldanamycin
I-5508 Imatinib, Methanesulfonate Salt
I-4944 Imiquimod, Free Base
I-5900 Ingenol 3-Angelate
I-9000 Ingenol 3-Angelate 20-Acetate
I-4122 Irinotecan, Hydrochloride Salt, Trihydrate
L-4804 Lapatinib, Di-p-Toluenesulfonate Salt
L-6307 Lestaurtinib
N-6011 Nedaplatin
M-7007 Masitinib, Free Base
M-5602 Mubritinib, Free Base
N-8207 Nilotinib, Free Base
N-4288 NVP-BEZ235, Free Base
O-5679 OSU-03012, Hydrochloride Salt
O-7111 Oxaliplatin
P-9600 Paclitaxel
P-6706 Pazopanib, Free Base
P-5411 Picoplatin
P-6040 Pimecrolimus
P-7600 PKC412
R-5000 Rapamycin
S-8411 Satraplatin
S-8599 Sorafenib, Free Base
S-8502 Sorafenib, p-Toluenesulfonate Salt
S-8877 Sunitinib, Free Base
S-8803 Sunitinib, Malate Salt
T-7802 Tandutinib, Free Base
T-8040 Temsirolimus
T-2304 Tozasertib, Free Base
V-9402 Vandetanib, Free Base
V-9077 Vargatef, Free Base
V-8303 Vatalanib, Dihydrochloride Salt
Z-9040 Zotarolimus
Z-1066 ZSTK474, Free Base

Anti-Neoplastic Compounds (See Anti-Cancer Compounds)

Apoptosis Reagents

B-8500 Brefeldin A
C-8700 Cyclopamine, Free Base

Alcohol Dehydrogenase Inhibitors

D-2946 Daidzein
D-7878 Daidzin

ATPase Inhibitors (See Also Ion-Modulating
Reagents—Ion Co-Transporters)

B-1080 Bafilomycin A1
T-3250 Thapsigargin

Calcineurin (See Protein Phosphatase 2B)

Calcium-Related Reagents

Calcium Releasers (from Intracellular Stores)
T-3250 Thapsigargin

Ion Channel Activators

Calcium/Divalent Cation Channel Activators
I-6400 5'-Iodoresiniferatoxin (5'-IRTX)
I-2000 6'-Iodoresiniferatoxin (6'-IRTX)
P-6388 PPAHV (Phorbol 12-Phenylacetate 13-Acetate 20-Homovanillate)
R-6712 Resiniferatoxin (RTX)
T-5096 Tinyatoxin (TYX)

TRPV Cation Channel Activators (a.k.a. OTRPCH, VR-OAC, TRP12, VRL-2)
P-1571 4α-Phorbol 12,13-Diacetate
P-4678 4α-Phorbol 12,13-Dibutyrate
P-2170 4α-Phorbol 12,13-Didecanoate
P-8880 4α-Phorbol 12-Myristate 13-Acetate

Ionophores, Calcium
I-5700 Ionomycin, Free Acid
I-6800 Ionomycin, Calcium Salt

Ion Transporter/Co-transporter Inhibitors (Ca2+)
T-3250 Thapsigargin

Capsaicin-Related Reagents

I-6400   5'-Iodoresiniferatoxin (5'-IRTX)
I-2000   6'-Iodoresiniferatoxin (6'-IRTX)
P-6388 PPAHV (Phorbol 12-Phenylacetate 13-Acetate 20-Homovanillate)
R-6712 Resiniferatoxin (RTX)
T-5096 Tinyatoxin (TYX)

cdc/cdk Kinases (See Cell Cycle Reagents)

Cell Cycle Reagents

Cyclin/cdc/cdk Kinases

Inhibitors
R-1234 Roscovitine, Free Base

Cholesterol-Lowering Drugs

A-2766 Atorvastatin, Hemicalcium Salt, Sesquihydrate

CSBP Kinase (See MEK and MEK Kinases)

Cyclic Nucleotide Reagents

See individual entries, e.g. Adenylate Cyclase,
Guanylate Cyclase, Phosphodiesterase, PKA, PKC, PKG

Cyclin/cdc/cdk Kinases (See Cell Cycle Reagents)

EGF Receptor Kinase Inhibitors (See also Tyrosine Kinase Reagents)

M-5602 Mubritinib, Free Base
T-7310 Tyrphostin AG 1478, Free Base

Endoplasmic Reticulum Reagents

B-8500 Brefeldin A
T-3250 Thapsigargin

Enzyme Activators and Inhibitors — See individual enzyme entries

ERK Kinase (See MEK and MEK Kinases)

FLK-1 (See VEGF Receptor Kinase)

Golgi Reagents

B-8500 Brefeldin A

Heat Shock Protein Modulators

A-6880 17-AAG
D-3440 17-DMAG, Hydrochloride Salt
G-4500 Geldanamycin

Hedgehog Inhibitors

C-8700 Cyclopamine, Free Base

Histamine Secretagogues

T-3250 Thapsigargin

Immunostimulants

I-4944 Imiquimod, Free Base

Immunosuppressants

A-1040 Ascomycin
C-1377 CP690550, Free Base
C-6000 Cyclosporin A
E-4040 Everolimus
F-4633 Fingolimod, Hydrochloride Salt
F-4900 FK-506
M-7800 Mycophenolic Acid, Free Acid
P-6040 Pimecrolimus
R-5000 Rapamycin
T-8040 Temsirolimus
Z-9040 Zotarolimus

Ion-Modulating Reagents

H+-ATPase Inhibitors (See also ATPase Inhibitors)
B-1080 Bafilomycin A1

Calcium Releasers (from Intracellular Stores)
T-3250 Thapsigargin

Ion Channel Activators

Calcium/Divalent Cation Channel Activators
I-6400 5'-Iodoresiniferatoxin (5'-IRTX)
I-2000 6'-Iodoresiniferatoxin (6'-IRTX)
P-6388 PPAHV (Phorbol 12-Phenylacetate 13-Acetate 20-Homovanillate)
R-6712 Resiniferatoxin (RTX)
T-5096 Tinyatoxin (TYX)

TRPV Cation Channel Activators (a.k.a. OTRPCH, VR-OAC, TRP12, VRL-2)
P-1571 4α-Phorbol 12,13-Diacetate
P-4678 4α-Phorbol 12,13-Dibutyrate
P-2170 4α-Phorbol 12,13-Didecanoate
P-8880 4α-Phorbol 12-Myristate 13-Acetate

Ionophores, Calcium
I-5700 Ionomycin, Free Acid
I-6800 Ionomycin, Calcium Salt

Ion Transporter/Co-transporter Inhibitors (Ca2+)
T-3250 Thapsigargin

Isoflavones (See Soybean Isoflavones)

JAK-2 Kinase Inhibitors

T-9142 Tyrphostin AG 490

JAK-3 Kinase Inhibitors

C-1377 CP690550, Free Base

Kinase Inhibitors, Non-Selective

P-7600 PKC412
S-9300 Staurosporine, Free Base

Leukotriene Receptor Antagonists

M-4966 Montelukast, Sodium Salt

MAP Kinases (See MEK and MEK Kinases)

MEK and MEK Kinases

Inhibitors
D-2744 Doramapimod, Free Base
P-4313 PD 98059
S-1700 SB 202190, Free Base
S-3400 SB 203580, Free Base
U-6770 U0126

Myosin Light Chain Kinase Reagents

Inhibitors
W-2990 Wortmannin

Neurochemicals

I-6400 5'-Iodoresiniferatoxin (5'-IRTX)
I-2000 6'-Iodoresiniferatoxin (6'-IRTX)
P-6388 PPAHV (Phorbol 12-Phenylacetate 13-Acetate 20-Homovanillate)
R-6712 Resiniferatoxin (RTX)
T-5096 Tinyatoxin (TYX)

Nuclear Export Inhibitors

L-6100 Leptomycin B, Free Acid (LMB)

p38 Kinase (See MEK and MEK Kinases)

p40 Kinase (See MEK and MEK Kinases)

Phosphatidylinositol 3-Kinase Inhibitors

L-7962 LY 294002
N-4288 NVP-BEZ235, Free Base
W-2990 Wortmannin

PI3-Kinase (See Phosphatidylinositol 3-Kinase Inhibitors)

Platinum-based Anti-Cancer Compounds

C-2411 Carboplatin
C-3011 Cisplatin
E-4111 Eptaplatin
N-6011 Nedaplatin
O-7111 Oxaliplatin
P-5411 Picoplatin
S-8411 Satraplatin

Proteasome Inhibitors

B-1408 Bortezomib, Free Base

Protein Kinase A (PKA)

PKA Inhibitors
F-4660 Fasudil, Monohydrochloride Salt
H-5239 H-89, Dihydrochloride Salt
H-2330 HA-1077, Dihydrochloride Salt
K-2151 K252a
K-9609 K252c
S-9300 Staurosporine, Free Base

Protein Kinase C (PKC)

PKC Activators

PKC-selective but not PKC Isotype-selective Activators
B-6697 Bryostatin 1
B-3517 Bryostatin 2
D-5571 12-Deoxyphorbol 13-Isobutyrate
D-8660 12-Deoxyphorbol 13-Phenylacetate
I-1711 (-)-Indolactam V
I-8560 Ingenol
M-2550 4-O-Methylphorbol 12-Myristate 13-Acetate
P-4227 Phorbol 13-Acetate
P-7350 Phorbol 13-Decanoate
P-5005 Phorbol 12,13-Diacetate
P-3106 Phorbol 12,13-Dibenzoate
P-4833 Phorbol 12,13-Dibutyrate
P-1925 Phorbol 12,13-Didecanoate
P-3814 Phorbol 12,13-Dihexanoate
P-1680 Phorbol 12-Myristate 13-Acetate
P-4462 Prostratin
R-8765 Resiniferonol 9,13,14-Orthophenylacetate

Negative Controls
P-1571 4α-Phorbol 12,13-Diacetate
P-4678 4α-Phorbol 12,13-Dibutyrate
P-2170 4α-Phorbol 12,13-Didecanoate
P-8880 4α-Phorbol 12-Myristate 13-Acetate

PKC Inhibitors

PKC-selective but not PKC Isotype-selective Inhibitors
B-2464 Bisindolylmaleimide I, Free Base
B-6191 Bisindolylmaleimide I, Hydrochloride Salt
C-3030 Chelerythrine Chloride

PKC Isotype-selective Inhibitors
G-6203 Gö 6976
R-9630 Rottlerin - SEE IMPORTANT NOTE!!

PKC Inhibitors not Selective for PKC or of Unknown Selectivity
H-5239 H-89, Dihydrochloride Salt
K-2151 K252a
K-9609 K252c
P-7600 PKC412
S-9300 Staurosporine, Free Base

Protein Kinase G (PKG)

PKG Inhibitors
F-4660 Fasudil, Monohydrochloride Salt
H-2330 HA-1077, Dihydrochloride Salt
K-2151 K252a
S-9300 Staurosporine, Free Base

Protein Kinase Inhibitors (see also individual enzymes)

Inhibitors
A-1107 Axitinib, Free Base
B-2464 Bisindolylmaleimide I, Free Base
B-6191 Bisindolylmaleimide I, Hydrochloride Salt
B-1709 Bosutinib, Free Base
C-1201 Canertinib, Dihydrochloride Salt
C-3030 Chelerythrine Chloride
C-1377 CP690550, Free Base
D-3307 Dasatinib, Free Base
D-3608 Dovitinib, Free Base
E-4007 Erlotinib, Hydrochloride Salt
F-4660 Fasudil, Monohydrochloride Salt
G-4408 Gefitinib, Free Base
G-6055 Genistein
G-6203 Gö 6976
H-5239 H-89, Dihydrochloride Salt
H-2330 HA-1077, Dihydrochloride Salt
I-5508 Imatinib, Methanesulfonate Salt
K-2151 K252a
K-9609 K252c
L-4804 Lapatinib, Di-p-Toluenesulfonate Salt
L-6307 Lestaurtinib
L-7962 LY 294002
M-7007 Masitinib, Free Base
M-5602 Mubritinib, Free Base
N-8207 Nilotinib, Free Base
O-5679 OSU-03012, Hydrochloride Salt
P-6706 Pazopanib, Free Base
P-4313 PD 98059
P-7600 PKC412
R-1234 Roscovitine, Free Base
S-1700 SB 202190, Free Base
S-3400 SB 203580, Free Base
S-8599 Sorafenib, Free Base
S-8502 Sorafenib, p-Toluenesulfonate Salt
S-7979 SP600125
S-9300 Staurosporine, Free Base
S-8877 Sunitinib, Free Base
S-8803 Sunitinib, Malate Salt
T-7802 Tandutinib, Free Base
T-2304 Tozasertib, Free Base
T-9142 Tyrphostin AG 490
T-7310 Tyrphostin AG 1478, Free Base
U-6770 U0126
V-9402 Vandetanib, Free Base
V-9077 Vargatef, Free Base
V-8303 Vatalanib, Dihydrochloride Salt
W-2990 Wortmannin
Z-1066 ZSTK474, Free Base

Protein Phosphatase 1 Reagents

Inhibitors
C-3987 Calyculin A
O-2220 Okadaic Acid, Free Acid
O-6410 Okadaic Acid, Ammonium Salt
O-7519 Okadaic Acid, Potassium Salt
O-5857 Okadaic Acid, Sodium Salt

Protein Phosphatase 2A Reagents

Inhibitors
C-3987 Calyculin A
O-2220 Okadaic Acid, Free Acid
O-6410 Okadaic Acid, Ammonium Salt
O-7519 Okadaic Acid, Potassium Salt
O-5857 Okadaic Acid, Sodium Salt

Protein Phosphatase 2B (Calcineurin) Reagents

Inhibitors
C-6000 Cyclosporin A

Related Reagents
A-1040 Ascomycin
E-4040 Everolimus
F-4900 FK-506
P-6040 Pimecrolimus
R-5000 Rapamycin
T-8040 Temsirolimus
Z-9040 Zotarolimus

Protein Trafficking Reagents

B-8500 Brefeldin A
L-6100 Leptomycin B, Free Acid (LMB)

Retinoid Receptor Modulators

Retinoid X Receptor Modulators
B-2422 Bexarotene, Free Acid

Rho-Associated Kinase II

Inhibitors
F-4660 Fasudil, Monohydrochloride Salt
H-2330 HA-1077, Dihydrochloride Salt

RK Kinase (See MEK and MEK Kinases)

Smoothened (Smo) Inhibitors

C-8700 Cyclopamine, Free Base

Soybean Isoflavone-Related Compounds

Soybean Constituents
A-6900 6"-O-Acetyldaidzin
A-3000 6"-O-Acetylgenistin
A-7860 6"-O-Acetylglycitin
D-2946 Daidzein
D-7878 Daidzin
G-6055 Genistein
G-5200 Genistin
G-1152 Glycitein
G-2822 Glycitin
M-6730 6"-O-Malonyldaidzin, Free Acid
M-8090 6"-O-Malonylgenistin, Free Acid
M-4620 6"-O-Malonylglycitin, Free Acid

Soybean Isoflavone Metabolites
D-9200 (R,S)-2,3-Dihydrodaidzein
E-5880 (R,S)-Equol

Sphingolipid Reagents

F-4633 Fingolimod, Hydrochloride Salt

Topoisomerase Inhibitors

I-4122 Irinotecan, Hydrochloride Salt, Trihydrate

TRPV Cation Channel Activators (a.k.a. OTRPCH, VR-OAC, TRP12, VRL-2)

P-1571 4α-Phorbol 12,13-Diacetate
P-4678 4α-Phorbol 12,13-Dibutyrate
P-2170 4α-Phorbol 12,13-Didecanoate
P-8880 4α-Phorbol 12-Myristate 13-Acetate

Tubulin Assembly/Stabilization Promoters

D-1000 Docetaxel
P-9600 Paclitaxel

VEGF Receptor Kinase Inhibitors

A-1107 Axitinib, Free Base
P-6706 Pazopanib, Free Base
V-9077 Vargatef, Free Base


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