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Z-9900 Z-VAD-FMK, Methyl Ester, >99%      NEW!

Synonyms:  [Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone] [Z-VAD(OMe)-FMK] [Z-Val-Ala-Asp(OMe)-FMK] [Z-Val-Ala-Asp-FMK, Methyl Ester]

M.W. 467.49

C22H30FN3O7

[187389-52-2]

Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO.  Disposal:  A

Find and View a Certificate of Analysis for this product

View the MSDS for this product

• Z-VAD-FMK is a caspase inhibitor and antiapoptotic agent.

• The apoptotic responses of human melanocytes to UV radiation, 4-tert-butylphenol, and cisplatin were associated with BH3 interacting domain cleavage, caspase activation, mitochondrial depolarization and release of cytochrome c, Smac/DIABLO, and apoptosis-inducing factor (AIF), but not endonuclease G.  Z-VAD-FMK was not able to block these apoptotic responses and AIF release, indicating that the apoptotic responses were caspase-independent.  Liu, T., et al.  "Activation of dual apoptotic pathways in human melanocytes and protection by survivin."  J. Invest. Dermatol. 126:  2247-2256 (2006).

• Z-VAD-FMK decreased TNF-induced enterocyte detachment and apoptosis as well as villus atrophy in mice.  Piguet, P.F., et al.  "TNF-induced enterocyte apoptosis and detachment in mice:  induction of caspases and prevention by a caspase inhibitor, ZVAD-fmk."  Lab. Invest. 79:  495-500 (1999).

• Z-VAD-FMK up-regulated caspase-9 activity, which was involved in an amplification loop of etoposide-induced cell death at the mitochondrial level in mouse embryonic fibroblasts.  Rodríguez-Enfedaque, A., et al.  "zVAD-fmk upregulates caspase-9 cleavage and activity in etoposide-induced cell death of mouse embryonic fibroblasts."  Biochim. Biophys. Acta. 1823:  1343-1352 (2012).

• Z-VAD-FMK increased cisplatin-induced renal damage.  Herzog, C., et al.  "zVAD-fmk prevents cisplatin-induced cleavage of autophagy proteins but impairs autophagic flux and worsens renal function."  Am. J. Physiol. Renal. Physiol. 303:  F1239-F1250 (2012).

• This Z-VAD-FMK product is the methyl ester.  We also offer the free acid form -- please see Cat. No. Z-9999, Z-VAD-FMK, Free Acid.

** Our prices are lower than other vendors', but there is no compromise in quality.  Read how we are able to accomplish this:  Product Quality Discussion.

NOTES:
1.  The purpose of our competitor price comparison tables is to enable our visitors to compare the prices and purities of products of nominally equivalent quality, for vendors whose price and purity claims are openly available from a website or catalog (without a need for the customer to contact the vendor and request a quotation in order to obtain a price and purity for a standard product size).  However, the quality comparisons in these tables are not absolute:  although our product purities are uniformly very high and are established by careful testing of every lot in our laboratories, we cannot and do not vouch for the purities claimed by other vendors in these competitor price comparison tables.  (We do carry out occasional testing of other vendors' products -- see below --  and we have found many instances where vendors' product purities are far below their claimed levels.)  Effective April 1, 2011, our price comparison tables only include products where a purity commitment is found together with sizes and prices on at least one page of the vendor's web site.

2.  Researching and compiling sizes and prices for the >160 competitive vendors and more than 175 products is an expensive and tedious task for our small company.  Thus, we typically only perform revisions of these tables annually or less frequently.  The date and source of each competitive vendor's prices is indicated at the bottom of this page.  Obviously, we make no guarantee that competitive vendor prices will remain unchanged in the interval between our annual revisions.  We may occasionally update individual competitive vendor information and add new competitive vendors as we locate them.

3.  In some circumstances we permanently remove vendors from our price comparison tables.  Circumstances that lead to permanent removal are: 

A.  If a vendor does not honor its advertised price (ignoring small price increases) for one or more products when an order is attempted.  Example:  a vendor listed a compound at $808 for 10 grams on its website price list, but quoted $4,500 per 10 grams upon our inquiry.  That vendor has been permanently removed from our price comparison tables.

B.  If, on a product-by-product basis, our analyses of a vendor's product show purities more than a few percent below the vendor's advertised purities.  Example:  a vendor advertises a purity for 97% for a compound, but repeated elemental analyses show a minimum of 9% inorganic material present, beyond any salt counterion.  Another example: an HPLC analysis at a relevant UV detector wavelength shows 92% purity for a vendor's product for which 98% purity is claimed.  We realize of course that UV absorbances for impurities can be higher than for the main compound, but our products meet our purity commitment of typically >99% irrespective of absorbance factors for impurities, and we apply that standard to products from other vendors.

C.  Again on a product-by-product basis, if a vendor makes no purity claim for a given product, then their product is not shown on that product table.

D.  If we find that, as a pattern, several of a competitive vendor's products fail to meet their advertised purity commitments by significant margins or if a vendor does not provide standard and consistent purity claims for several of its products, then that vendor is permanently removed from all of our competitor price tables.

E.  Finally, if we determine that a vendor has provided fraudulent information on its website, in its literature or on a certificate of analysis, that vendor is permanently removed from all of our price comparison tables.

4.  IMPORTANT:  The presence of a competitive vendor entry in our price comparison tables does not necessarily mean that we have analyzed any of that vendor's products for purity; indeed, in most cases we have not.

5.  Please note:  where necessary, competitor prices are rounded to the nearest whole dollar.

To the best of our knowledge, the prices listed above for our competitors' products were correct as of the dates listed below for the sources of our annual price information update process.

Pricing Sources and Dates:  LC Labs - Current, Sigma-Aldrich - website - Jan 2013, Enzo Life Sciences - website - Jan 2013, AG Scientific - website - Jan 2013, Axxora - website - Jan 2013, Santa Cruz Biotech - website - Jan 2013, US Biological - website - Mar 2013, Invivogen - website - Jan 2013, VDM Biochemicals - website - Dec 2012, AdipoGen - website - Sep 2012, Abcam - website - Dec 2012, Gojira Fine Chemicals - website - Dec 2012.