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In Business 33 Years - Since 1980 |
THE CURRENT TIME at LC Labs is: |
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Size |
US $ |
€ |
£ |
¥ |
|
||
|
25 mg |
32 |
25 |
21 |
4200 |
| ||
|
50 mg |
43 |
34 |
28 |
5700 |
| ||
|
100 mg |
75 |
58 |
49 |
9900 |
| ||
|
200 mg |
138 |
108 |
91 |
18200 |
| ||
|
250 mg |
159 |
124 |
105 |
20900 |
| ||
|
1 g |
314 |
245 |
207 |
41400 |
| ||
|
2 g |
584 |
455 |
385 |
76900 |
| ||
Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
| Compare Prices and Purity LC Labs vs. Other Suppliers | Printable Version |
|---|
M.W. 417.41
C19H21F2N7O2
[475110-96-4]
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 20 mg/mL; soluble in ethanol at 2.5 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-5 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A
Find and View a Certificate of Analysis for this product
View the MSDS for this product
ZSTK474, a novel s-triazine derivative, binds to the ATP-binding site of Class I phosphatidylinositol 3-kinases (PI3K) and inhibits PI3K activity. ZSTK474 has strong antitumor activities against human cancer xenografts (A549, PC-3 and WiDr) when administered orally to mice. Furthermore, ZSTK474 did not show significant toxicity at the doses tested. Yaguchi, S., et al. "Antitumor Activity of ZSTK474, a New Phosphatidylinositol 3-Kinase Inhibitor." J. Natl. Cancer Inst. 98: 545-556 (2006).
The Class I PI3K inhibitory activity of ZSTK474 is not isoform-specific within the class -- it is an ATP-competitive inhibitor of all four Class I PI3K isoforms. However, ZSTK474 inhibits PI3Kδ most potently, with a Ki of 1.8 nM, while it inhibits the α, β and γ isoforms at slightly higher concentrations (6.7 nM, 10.4 nM and 11.7 nM, respectively). Kong, D. and Yamori, T. "ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms." Cancer Sci. 98: 1638-1642 (2007).
ZSTK474 is a far more potent Class I PI3K inhibitor than LY294002, by a factor of 30-fold or more, and it is far more stable than wortmannin. Kong, D. and Yamori, T., ibid.
ZSTK474 is also less toxic than LY 294002 and wortmannin in animal model tests. Yaguchi, S., et al., op. cit.
Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.
Not available in some countries; not available to some institutions; not available for some uses.
Click here for printable/downloadable PDF version of this price comparison table
Purity and Price Comparisons ** |
Z-1066 ZSTK474, Free Base |
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Prices in US Dollars ($) |
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| Company |
Cat. No. |
Purity |
5 mg |
10 mg |
20 mg |
25 mg |
50 mg |
100 mg |
200 mg |
250 mg |
1 g |
2 g |
| ||||||||||||
LC Labs |
Z-1066 |
99 % |
|
|
|
32 |
43 |
75 |
138 |
159 |
314 |
584 |
Active Biochem |
A-1055 |
99 % |
|
60 |
100 |
|
220 |
|
|
|
|
|
US Biological |
Z0886-50 |
99 % |
|
|
|
|
150 |
|
|
|
|
|
PharmBlock |
cc503 |
98 % |
|
95 |
|
|
295 |
495 |
695 |
|
|
|
Echelon Biosciences |
B-0307 |
99 % |
65 |
|
|
94 |
|
185 |
|
|
|
|
BePharm |
B160720 |
95 % |
|
|
|
|
|
|
|
|
750 |
|
Cambridge BioScience |
1597 |
99 % |
|
|
|
154 |
|
316 |
|
|
|
|
Chemdea |
CD0237 |
99 % |
|
25 |
|
37 |
49 |
86 |
|
185 |
352 |
|
biorbyt.com |
orb61122 |
99 % |
|
|
|
|
176 |
208 |
320 |
368 |
|
|
Reagents Direct |
86-M73 |
98 % |
|
|
|
|
99 |
|
|
|
|
|
biokits.com |
1597 |
99 % |
|
|
|
95 |
|
195 |
|
|
|
|
HuoLi Biochem |
A-1055 |
99 % |
|
60 |
100 |
|
220 |
|
|
|
|
|
Acesobio |
cc503 |
98 % |
|
60 |
|
|
245 |
450 |
695 |
|
|
|
P212121 |
LC-Z-1066 |
99 % |
|
|
|
82 |
94 |
127 |
192 |
213 |
373 |
651 |
Ark Pharm |
AK-40326 |
95 % |
|
|
|
|
|
|
|
300 |
750 |
|
Medchem Express |
HY-50847 |
98 % |
|
|
|
|
75 |
|
|
300 |
|
|
AdooQ BioScience |
A11014 |
98 % |
|
55 |
|
120 |
220 |
380 |
|
|
|
|
EMMX BioChemicals |
E10533 |
99 % |
|
55 |
|
120 |
220 |
380 |
|
|
|
|
ChemScene |
CS-0083 |
98 % |
|
|
|
|
82 |
|
|
330 |
|
|
Kinasechem |
K1164 |
99 % |
40 |
76 |
|
138 |
|
237 |
|
|
|
|
Savings
with |
|
|
|
|
|
14 - 79% |
12 - 85% |
13 - 85% |
28 - 80% |
14 - 57% |
11 - 58% |
10 - 10% |
** Our prices are lower than other vendors', but there is no compromise in quality. Read how we are able to accomplish this: Product Quality Discussion.
NOTES:
1. The purpose of our competitor price comparison tables is to enable our visitors to compare the prices and purities of products of nominally equivalent quality, for vendors whose price and purity claims are openly available from a website or catalog (without a need for the customer to contact the vendor and request a quotation in order to obtain a price and purity for a standard product size). However, the quality comparisons in these tables are not absolute: although our product purities are uniformly very high and are established by careful testing of every lot in our laboratories, we cannot and do not vouch for the purities claimed by other vendors in these competitor price comparison tables. (We do carry out occasional testing of other vendors' products -- see below -- and we have found many instances where vendors' product purities are far below their claimed levels.) Effective April 1, 2011, our price comparison tables only include products where a purity commitment is found together with sizes and prices on at least one page of the vendor's web site.
2. Researching and compiling sizes and prices for the >160 competitive vendors and more than 175 products is an expensive and tedious task for our small company. Thus, we typically only perform revisions of these tables annually or less frequently. The date and source of each competitive vendor's prices is indicated at the bottom of this page. Obviously, we make no guarantee that competitive vendor prices will remain unchanged in the interval between our annual revisions. We may occasionally update individual competitive vendor information and add new competitive vendors as we locate them.
3. In some circumstances we permanently remove vendors from our price comparison tables. Circumstances that lead to permanent removal are:
A. If a vendor does not honor its advertised price (ignoring small price increases) for one or more products when an order is attempted. Example: a vendor listed a compound at $808 for 10 grams on its website price list, but quoted $4,500 per 10 grams upon our inquiry. That vendor has been permanently removed from our price comparison tables.
B. If, on a product-by-product basis, our analyses of a vendor's product show purities more than a few percent below the vendor's advertised purities. Example: a vendor advertises a purity for 97% for a compound, but repeated elemental analyses show a minimum of 9% inorganic material present, beyond any salt counterion. Another example: an HPLC analysis at a relevant UV detector wavelength shows 92% purity for a vendor's product for which 98% purity is claimed. We realize of course that UV absorbances for impurities can be higher than for the main compound, but our products meet our purity commitment of typically >99% irrespective of absorbance factors for impurities, and we apply that standard to products from other vendors.
C. Again on a product-by-product basis, if a vendor makes no purity claim for a given product, then their product is not shown on that product table.
D. If we find that, as a pattern, several of a competitive vendor's products fail to meet their advertised purity commitments by significant margins or if a vendor does not provide standard and consistent purity claims for several of its products, then that vendor is permanently removed from all of our competitor price tables.
E. Finally, if we determine that a vendor has provided fraudulent information on its website, in its literature or on a certificate of analysis, that vendor is permanently removed from all of our price comparison tables.
4. IMPORTANT: The presence of a competitive vendor entry in our price comparison tables does not necessarily mean that we have analyzed any of that vendor's products for purity; indeed, in most cases we have not.
5. Please note: where necessary, competitor prices are rounded to the nearest whole dollar.
To the best of our knowledge, the prices listed above for our competitors' products were correct as of the dates listed below for the sources of our annual price information update process.
Pricing Sources and Dates: LC Labs - Current, Active Biochem - website - Mar 2013, US Biological - website - Mar 2013, PharmBlock - website - Apr 2013, Echelon Biosciences - website - Dec 2012, BePharm - website - May 2013, Cambridge BioScience - website - Oct 2012, Chemdea - website - Dec 2012, biorbyt.com - website - Jan 2013, Reagents Direct - website - Dec 2012, biokits.com - website - Jan 2013, HuoLi Biochem - website - Jan 2013, Acesobio - website - Jan 2013, P212121 - website - Oct 2012, Ark Pharm - website - Dec 2012, Medchem Express - website - Jan 2013, AdooQ BioScience - website - Jan 2013, EMMX BioChemicals - website - Jan 2013, ChemScene - website - Jan 2013, Kinasechem - website - Apr 2013.
Our products are for laboratory research only and are sold only to qualified research institutions, not to individuals or patients nor for veterinary use.