In Business 32 Years - Since 1980
THE CURRENT TIME at LC Labs is:
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In Business 32 Years - Since 1980 |
THE CURRENT TIME at LC Labs is: |
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[KY 12420]
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Size |
US $ |
€ |
£ |
¥ |
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10 mg |
27 |
21 |
17 |
2100 |
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25 mg |
59 |
45 |
37 |
4500 |
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50 mg |
111 |
84 |
70 |
8500 |
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100 mg |
206 |
156 |
130 |
15800 |
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300 mg |
525 |
399 |
332 |
40200 |
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1 g |
1635 |
1242 |
1033 |
125300 |
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Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
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M.W. 428.43
C23H24O8
[19545-26-7]
M.I. 12: 10188
M.I. 14: 10053
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A
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View the MSDS for this product
Isolated from the filamentous fungus, Penicillium funiculosum, wortmannin is a potent, irreversible, and specific inhibitor of phosphatidylinositol 3-kinase (PI3-K) with an IC50 of 2-5 nM. Arcaro, A., and Wymann, M.P. "Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses." Biochem. J. 296: 297-301 (1993). Wymann, M.P., and Arcaro, A. "Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts." Biochem. J. 298: 517-520 (1994). Powis, G., et al. "Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase." Cancer Res. 54: 2419-2423 (1994). Wymann, M.P., et al. "Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction." Mol. Cell Biol. 16: 1722-1733 (1996).
Inhibitor of both myosin light chain kinase (IC50 = 200 nM) and phosphatidylinositol 4-kinase at concentrations approximately 100-fold higher than the that required for PI3-K inhibition. Nakanishi, S., et al. "Wortmannin, a microbial product inhibitor of myosin light chain kinase." J. Biol. Chem. 267: 2157-2163 (1992).
Enhances radiation- or serum withdrawal-induced apoptosis through the inhibition of PI3-K/Akt signal transduction cascade and blocks the antiapoptotic effect of cytokines. Krasilnikov, M., et al. "Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells." Mol. Carcinog. 24: 64-69 (1999). Allen, M.P., et al. "Growth arrest-specific gene 6/adhesion related kinase signaling promotes gonadotropin-releasing hormone neuronal survival via extracellular signal-regulated kinase (ERK) and Akt." Mol. Endocrinol. 13: 191-201 (1999). Morita, Y., et al. "Requirement for phosphatidylinositol-3'-kinase in cytokine-mediated germ cell survival during fetal oogenesis in the mouse." Endocrinology 140: 941-949 (1999). Manna, S.K., and Aggarwal, B.B. "Interleukin-4 down-regulates both forms of tumor necrosis factor receptor and receptor-mediated apoptosis, NFkappaB, AP-1, and c-Jun N-terminal kinase." J. Biol. Chem. 273: 33333-33341 (1998). Crowder, R.J., and Freeman, R.S. "Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons." J. Neurosci. 18: 2933-2943 (1998).
Wortmannin inhibition of PI3-K also blocks many of the short-term metabolic effects induced by insulin receptor activation in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Okada, T., et al. "Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin." J. Biol. Chem. 269: 3568-3573 (1994). Moule, S.K., and Denton, R.M. "Multiple signaling pathways involved in the metabolic effects of insulin." Am. J. Cardiol. 80: 41A-49A (1997).
Inhibits platelet activating factor-induced MAP kinase activation in guinea pig neutrophils (200 - 300 nM). Ferby, I.M., et al. "Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils." J. Biol. Chem. 269: 30485-30488 (1994).
Inhibits phospholipase D activation. Bonser, R.W., et al. "Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil." Br. J. Pharmacol. 103: 1237-1241 (1991).
Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
Our products are for laboratory research only and are sold only to qualified research institutions, not to individuals or patients nor for veterinary use.
