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U-6770 U0126, >99%

[1,4-Diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)-butadiene] [U-0126] [U 0126]

M.W. 380.50

C18H16N6S2

[109511-58-2]

Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO.  Appearance:  White solid.  Disposal:  A

View the MSDS for this product

• Selective inhibitor of the mitogen-activated protein kinase kinases, MEK-1 and MEK-2, with 100-fold higher potency than PD 98059, but is, at most, a weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.  U0126 is an inhibitor of AP-1 transactivation in cell-based reporter assays.  Favata, M.F., et al.  "Identfication of a novel inhibitor of mitogen-activated protein kinase kinase."  J. Biol. Chem. 273:  18623-18632 (1998).  DeSilva, D.R., et al.  "Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy."  J. Immuol. 160:  4175-4181 (1998).  Scherle, P.A., et al.  "Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes."  J. Immuol. 161:  5681-5686 (1998).

• Our U0126 is highly purified.  In crystalline form and in aprotic solvents it is a single chemical entity.  However, it appears that, in solution in protic solvents, U0126 exists as a mixture of isomers.  This phenomenon does not affect overall biological activity.  Note that DMSO normally contains water so that it behaves, in this case, as a protic solvent.  (LC Laboratories, unpublished results.)

• Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.