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[AG 1478]
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Size |
US $ |
€ |
£ |
¥ |
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25 mg |
49 |
41 |
27 |
5900 |
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100 mg |
150 |
125 |
83 |
18000 |
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500 mg |
590 |
490 |
325 |
70800 |
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1 g |
985 |
818 |
542 |
118200 |
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| US Dollars ($) | European Union Euros (€) | British Pounds (£) | Japanese Yen (¥) |
M.W. 315.76
C16H14ClN3O2
[175178-82-2]
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO, to about 60 mg/ml; poorly soluble in ethanol. Appearance: White solid. Disposal: A
View the MSDS for this product
Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM). Very weak on PDGF receptor and HER2-NEU kinases (IC50 >100 µM). Osherov, N. and Levitzki, A. "Epidermal-growth-factor-dependent activation of the src-family kinases." Eur. J. Biochem. 225: 1047-1053 (1994). Levitzki, A. and Gazit, A. "Tyrosine kinase inhibition: an approach to drug development." Science 267: 1782-1788 (1995).
Reversibly inhibits (IC50 = 9.8 µM) the rat brain Kv1.5 potassium channel in vitro in a non-protein-tyrosine-kinase-mediated manner. Choi, B.H., et al. "Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor." Am. J. Physiol. Cell Physiol. 282: C1461-C1468 (2002).
This product is the free base, which is best dissolved in DMSO. Please note that we also offer the methanesulfonate ("mesylate") salt under Cat. No. T-3655, Tyrphostin AG 1478, Methanesulfonate Salt, which is easily dissolved in aqueous Captisol (β-cyclodextrin hepta-sulfobutyl ether).
Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.
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