In Business 32 Years - Since 1980
THE CURRENT TIME at LC Labs is:
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In Business 32 Years - Since 1980 |
THE CURRENT TIME at LC Labs is: |
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[AG 1478]
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Size |
US $ |
€ |
£ |
¥ |
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|
25 mg |
71 |
54 |
45 |
5400 |
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|
100 mg |
219 |
166 |
138 |
16800 |
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500 mg |
725 |
551 |
458 |
55600 |
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1 g |
1160 |
881 |
733 |
88900 |
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Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
| Compare Prices and Purity — LC Labs vs. Other Suppliers |
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M.W. 315.75
C16H14ClN3O2
[175178-82-2]
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO, to about 60 mg/ml; poorly soluble in ethanol. Appearance: White solid. Disposal: A
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View the MSDS for this product
Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM). Very weak on PDGF receptor and HER2-NEU kinases (IC50 >100 µM). Osherov, N. and Levitzki, A. "Epidermal-growth-factor-dependent activation of the src-family kinases." Eur. J. Biochem. 225: 1047-1053 (1994). Levitzki, A. and Gazit, A. "Tyrosine kinase inhibition: an approach to drug development." Science 267: 1782-1788 (1995).
Reversibly inhibits (IC50 = 9.8 µM) the rat brain Kv1.5 potassium channel in vitro in a non-protein-tyrosine-kinase-mediated manner. Choi, B.H., et al. "Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor." Am. J. Physiol. Cell Physiol. 282: C1461-C1468 (2002).
Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
Our products are for laboratory research only and are sold only to qualified research institutions, not to individuals or patients nor for veterinary use.
