In Business 32 Years - Since 1980
THE CURRENT TIME at LC Labs is:
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In Business 32 Years - Since 1980 |
THE CURRENT TIME at LC Labs is: |
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Size |
US $ |
€ |
£ |
¥ |
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1 mg |
32 |
24 |
20 |
2500 |
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5 mg |
139 |
106 |
88 |
10700 |
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10 mg |
245 |
186 |
155 |
18800 |
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25 mg |
495 |
376 |
313 |
37900 |
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Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
| Compare Prices and Purity — LC Labs vs. Other Suppliers |
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M.W. 650.75
C34H50O12
[67526-95-8]
M.I. 14: 9272
WARNING: Highly irritant to skin and mucous membranes. SPECIAL HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol. Disposal: A
Find and View a Certificate of Analysis for this product
View the MSDS for this product
Potent, cell permeable IP3-independent intracellular calcium releaser. Takemura, H., et al. "Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membrane." J. Biol. Chem. 264: 12266-12271 (1989).
Inhibits microsomal Ca2+-ATPase. Thastrup, O., et al. "Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage." Agents Actions 27: 17-23 (1989).
Rat mast cell histamine secretagogue. Rasmussen, U.S.B., et al. "Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica" Acta Pharm. Suecica 15: 133-140 (1978). Patkar, S.A., et al. "On the mechanism of histamine release induced by thapsigargin from Thapsia garganica L." Agents Actions 9: 53-57 (1979).
Mouse skin tumor promoter with potency somewhat weaker than teleocidin or PMA, but does not bind to protein kinase C or induce ornithine decarboxylase activity. Hakii, H., et al. "Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanoylphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesis." J. Cancer Res. Clin. Oncol. 111: 177-181 (1986).
Stimulates arachidonic acid metabolism in macrophages. Ohuchi, K., et al. "Stimulation of arachidonic acid metabolism in rat peritoneal macrophages by thapsigargin, a non-(12-O-tetradecanoylphorbol-13-acetate) (TPA)-type tumor promoter." J. Cancer Res. Clin. Oncol. 113: 319-324 (1987).
Please request Technical Note #15 for additional information.
Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
Our products are for laboratory research only and are sold only to qualified research institutions, not to individuals or patients nor for veterinary use.
