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S-8877 Sunitinib, Free Base, >99%

[SU-11248] [Sutent] [PHA-290940AD] [PNU-290940AD]

M.W. 398.47

C22H27FN4O2

[557795-19-4]

M.I. 14:  9000

Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 40 mg/mL; soluble in ethanol at 1.4 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A

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• This is the free base form of sunitinib; please see our product Sunitinib, Malate Salt, Cat. No. S-8803, for further technical information.  The malate salt form of sunitinib, not the free base, is used in the sunitinib formulation for use in humans.

• Sunitinib (as the malate salt) is the active ingredient in the drug sold under the trade name Sutent.  This drug is a small molecule receptor tyrosine kinase inhibitor that has been approved in at least one country for the treatment of patients having gastrointestinal stromal tumors or renal cell carcinomas.  NOTE:  The sunitinib malate sold by LC Laboratories is NOT Sutent®, and is NOT for human use.

• Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.

• This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.

• Not available in some countries; not available to some institutions; not available for some uses.