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S-8599 Sorafenib, Free Base, >99%

[Bay 43-9006] [Nexavar]

M.W. 464.82

C21H16ClF3N4O3

[284461-73-0]

M.I. 14:  8720

Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 200 mg/mL; soluble in ethanol at 3.3 mg/mL with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A

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• This is the free base form of sorafenib; please see our product Sorafenib, p-Toluenesulfonate Salt, Cat. No. S-8502, for further technical information.  It is the p-toluenesulfonate salt form, not the free base, that is used in the formulation of sorafenib for in vivo use.

• Sorafenib is the active ingredient in the drug sold under the trade name Nexavar®.  This drug has been approved in at least one country for use in patients with advanced renal cell cancer.  NOTE:  The sorafenib sold by LC Laboratories is NOT Nexavar®, and is NOT for human use.

• Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.

• This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.

• Not available in some countries; not available to some institutions; not available for some uses.