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S-1700 SB 202190, >99%

[FHPI] [4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole] [SB202190] [SB-202190]

S-1700PR

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M.W. 331.35

C₂₀H₁₄FN₃O

[152121-30-7]

Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A

SB202190, a pyridinyl imidazole, inhibits p38 kinase activity in vivo through competition with ATP. Young, P.R., et al. "Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site." J. Biol. Chem. 272: 12116-12121 (1997).

Induces apoptosis through activation of cysteine protease (CPP32)-like caspases . Nemoto, S., et al. "Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase." J Biol Chem. 273: 16415-16420 (1998).

Blocks both lipopolysaccharide (LPS)-induced gene expression and nitric oxide (NO)-induced stabilization of interleukin (IL)-8 mRNA in monocytes. Manthey, C.L., et al. "SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes." J. Leukoc. Biol. 64: 409-417 (1998). Ma, P., et al. "Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation." J. Leukoc. Biol. 76: 278-287 (2004).

Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.

SB 202190