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R-1234 Roscovitine, Free Base, >99%

[CYC202] [Seliciclib] [6-Benzylamino-2[(R)-(1'-ethyl-2'-hydroxyethylamino)]-9-isopropylpurine] [CYC-202] [CYC 202]

M.W. 354.45

C19H26N6O

[186692-46-6]

M.I. 14:  10240

Storage:  Store at or below -20 ºC.  Solubility:  Prepare initial stock solutions in DMSO (soluble at 200 mg/mL) or ethanol (soluble at 200 mg/mL) for in vitro use; solubility in water is low.  Appearance:  White to off-white powder.  Disposal:  A

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• Roscovitine is a potent inhibitor of p34cdc2 (IC50 = 0.2 µM).  Also inhibits p33cdk2 and p33cdk5.  Havlicek, L., et al.  "Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds."  J. Med. Chem. 40:  408-412 (1997).

• NOTE:  The word "Roscovitine" inherently means the R-isomer.

• Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.

• This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.

• Not available in some countries; not available to some institutions; not available for some uses.