In Business 32 Years - Since 1980
THE CURRENT TIME at LC Labs is:
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In Business 32 Years - Since 1980 |
THE CURRENT TIME at LC Labs is: |
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[Taxol]
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Size |
US $ |
€ |
£ |
¥ |
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||
|
100 mg |
43 |
33 |
27 |
3300 |
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|
250 mg |
89 |
68 |
56 |
6800 |
| ||
|
500 mg |
126 |
96 |
80 |
9700 |
| ||
|
1 g |
233 |
177 |
147 |
17900 |
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|
2 g |
428 |
325 |
271 |
32800 |
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5 g |
975 |
741 |
616 |
74700 |
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10 g |
1690 |
1284 |
1068 |
129600 |
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Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
| Compare Prices and Purity — LC Labs vs. Other Suppliers |
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M.W. 853.91
C47H51NO14
[33069-62-4]
M.I. 12: 7117
M.I. 14: 6982
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO (up to about 200 mg/mL) or ethanol (up to about 40 mg/mL). Disposal: A
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View the MSDS for this product
Antitumor and antileukemic agent isolated from the bark of the yew tree, Taxus brevifolia. Wani, M.C., et al. "Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia." J. Am. Chem. Soc. 93: 2325-2327 (1971). McGuire, W.P., et al. "Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms" Ann. Int. Med. 111: 273-279 (1989).
Binds to β-tubulin and promotes the assembly of microtubules that resist depolymerization preventing normal cell division. Rowinsky, E.K., et al. "Taxol: a novel investigational antimicrotubule agent." J. Natl. Cancer Inst. 82: 1247-1259 (1990). Parekh, H. and Simpkins, H. "The transport and binding of taxol." Gen. Pharmacol. 29: 167-172 (1997). Jordan, A., et al. "Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle investigational antimicrotubule agent." Med. Res. Rev. 18: 259-296 (1998).
Induces apoptosis through a JNK-dependent pathway in the early phase followed by a JNK-independent pathway that results in Bcl-2 phosphorylation. Wang, T.H., et al. "Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-termnial kinase (JNK)-dependent and -independent pathways in overian cancer cells." J. Biol. Chem. 274: 8208-8216 (1999). Shtil, A.A., et al. "Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells." Oncogene 18: 377-384 (1999). Srivastava, R.K., et al. "Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase." Mol. Cell. Biol. 18: 3509-3517 (1998). Torres, K., and Horwitz, S.B. "Mechanisms of Taxol-induced cell death are concentration dependent." Cancer Res. 58: 3620-3626 (1998).
Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
Our products are for laboratory research only and are sold only to qualified research institutions, not to individuals or patients nor for veterinary use.
