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P-7177 Pemetrexed, Disodium Salt, Heptahydrate, >99%

[Alimta] [LY-231514] [MTA] [Rolazar] [Tifolar] [LY-231514] [LY-231514]

M.W. 597.48

C20H19N5Na2O6•7H2O

[357166-29-1]

M.I. 14:  7077

Storage:  Store at or below -20 ºC.  Solubility:  Very poorly soluble in DMSO; very poorly soluble in ethanol; soluble in water at 100 mg/mL; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A

Find and View a Certificate of Analysis for this product

View the MSDS for this product

• Pemetrexed inhibits dihydrofolate reductase, thymidylate synthase and glycinamide ribonucleotide formyltransferase with Ki values of 7 nM, 109 nM and 9.3 µM, respectively.  Shih, C., et al.  "LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes."  Cancer Res. 57:  1116-1123 (1997).

• Pemetrexed inhibits the proliferation of various human tumor cell lines, including CCRF-CEM leukemia, GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells.  Thymidine demonstrated its greatest protective effect at the IC50 of pemetrexed.  However, higher drug concentrations of pemetrexed required the combination of both thymidine plus hypoxanthine to protect the tumor cells.  Shih, C., et al.  "LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes."  Cancer Res. 57:  1116-1123 (1997).

• The addition of folic acid supplementation with some antifolates substantially diminished the host toxicity.  However, natural folates inhibited the activity of pemetrexed by suppressing folylpolyglutamate synthetase and thus decreasing the levels of active folylpolyglutamate pemetrexed congeners.  Zhao, R., et al.  "Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells."  Biochem. Pharmacol. 61:  857-865 (2001).

• The membrane transport system for pemetrexed includes reduced folate carrier (RFC), folate receptors, a folate transport carrier with a low-pH optimum, and RFC-independent transport at neutral pH, etc.  Chattopadhyay, S., et al.  "Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications."  Mol. Cancer Ther. 6:  404-417 (2007).

• Pemetrexed was approved in combination with cisplatin for the treatment of pleural mesothelioma in 2004.  Hazarika, M., et al.  "FDA drug approval summaries: pemetrexed (Alimta®)."  Oncologist 9:  482-488 (2004).

• Pemetrexed was also approved for the second-line treatment of locally advanced or metastatic non-small cell lung cancer in 2004.  Cohen, M.H., et al.  "FDA drug approval summary: pemetrexed for injection (Alimta®) for the treatment of non-small cell lung cancer."  Oncologist 10:  363-368 (2005).

• Pemetrexed is the active ingredient in the drug sold under the trade name Alimta®.  This drug has been approved in at least one country for use in patients with pleural mesothelioma as well as non-small cell lung cancer.  NOTE:  The pemetrexed product sold by LC Laboratories is NOT Alimta® and is NOT for human use.

• Our pemetrexed product is the disodium salt heptahydrate, whose CAS number is given above. The following CAS numbers correspond to other forms of pemetrexed: 137281-23-3 for the free acid; 150399-23-8 for the anhydrous disodium salt, and 357166-30-4 for the disodium salt "hemipentahydrate" (2.5 H2O).

• NOTE:  Water content may vary from lot to lot.  Please refer to the elemental analysis provided in the Certificate of Analysis to obtain the water content for each lot.

• Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.

• This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.

• Not available in some countries; not available to some institutions; not available for some uses.

** Our prices are lower than other vendors', but there is no compromise in quality.  Read how we are able to accomplish this:  Product Quality Discussion.

NOTES:
1.  The purpose of our competitor price comparison tables is to enable our visitors to compare the prices and purities of products of nominally equivalent quality, for vendors whose price and purity claims are openly available from a website or catalog (without a need for the customer to contact the vendor and request a quotation in order to obtain a price and purity for a standard product size).  However, the quality comparisons in these tables are not absolute:  although our product purities are uniformly very high and are established by careful testing of every lot in our laboratories, we cannot and do not vouch for the purities claimed by other vendors in these competitor price comparison tables.  (We do carry out occasional testing of other vendors' products -- see below --  and we have found many instances where vendors' product purities are far below their claimed levels.)  Effective April 1, 2011, our price comparison tables only include products where a purity commitment is found together with sizes and prices on at least one page of the vendor's web site.

2.  Researching and compiling sizes and prices for the >160 competitive vendors and more than 175 products is an expensive and tedious task for our small company.  Thus, we typically only perform revisions of these tables annually or less frequently.  The date and source of each competitive vendor's prices is indicated at the bottom of this page.  Obviously, we make no guarantee that competitive vendor prices will remain unchanged in the interval between our annual revisions.  We may occasionally update individual competitive vendor information and add new competitive vendors as we locate them.

3.  In some circumstances we permanently remove vendors from our price comparison tables.  Circumstances that lead to permanent removal are: 

A.  If a vendor does not honor its advertised price (ignoring small price increases) for one or more products when an order is attempted.  Example:  a vendor listed a compound at $808 for 10 grams on its website price list, but quoted $4,500 per 10 grams upon our inquiry.  That vendor has been permanently removed from our price comparison tables.

B.  If, on a product-by-product basis, our analyses of a vendor's product show purities more than a few percent below the vendor's advertised purities.  Example:  a vendor advertises a purity for 97% for a compound, but repeated elemental analyses show a minimum of 9% inorganic material present, beyond any salt counterion.  Another example: an HPLC analysis at a relevant UV detector wavelength shows 92% purity for a vendor's product for which 98% purity is claimed.  We realize of course that UV absorbances for impurities can be higher than for the main compound, but our products meet our purity commitment of typically >99% irrespective of absorbance factors for impurities, and we apply that standard to products from other vendors.

C.  Again on a product-by-product basis, if a vendor makes no purity claim for a given product, then their product is not shown on that product table.

D.  If we find that, as a pattern, several of a competitive vendor's products fail to meet their advertised purity commitments by significant margins or if a vendor does not provide standard and consistent purity claims for several of its products, then that vendor is permanently removed from all of our competitor price tables.

E.  Finally, if we determine that a vendor has provided fraudulent information on its website, in its literature or on a certificate of analysis, that vendor is permanently removed from all of our price comparison tables.

4.  IMPORTANT:  The presence of a competitive vendor entry in our price comparison tables does not necessarily mean that we have analyzed any of that vendor's products for purity; indeed, in most cases we have not.

5.  Please note:  where necessary, competitor prices are rounded to the nearest whole dollar.

To the best of our knowledge, the prices listed above for our competitors' products were correct as of the dates listed below for the sources of our annual price information update process.

Pricing Sources and Dates:  LC Labs - Current, Santa Cruz Biotech - website - Jan 2013, Cayman Chemical - website - Apr 2013, Active Biochem - website - Mar 2013, US Biological - website - Mar 2013, Focus Synthesis - website - Apr 2012, Key Organics - website - May 2013, BePharm - website - May 2013, AK Scientific - website - Mar 2013, ChemieTek - website - Jun 2013, Carbone Scientific - website - Jan 2013, biorbyt.com - website - Jan 2013, HuoLi Biochem - website - Jan 2013, ChemReagents.com - website - Oct 2012, P212121 - website - Oct 2012, Stru Chem - website - Dec 2011, MedKoo BioSciences - website - Apr 2013, Medchem Express - website - Jun 2013, Affix Scientific - website - Jan 2013, Synergy Scientific - website - Dec 2012, Kinasechem - website - Apr 2013.

^† Note:  Santa Cruz Biotech's product sc-219564, ChemieTek's product CT-PEME, Focus Synthesis' product FS200144, AK Scientific's product H518, Carbone Scientific's product C-22714, ChemReagents.com's product 80017208, Stru Chem's product SC-15901, MedKoo's product 100710, MedChem Express' product HY-10820A, Affix Scientific's product AF3093, and Kinasechem's product K1283 are the anhydrous, disodium salt form of this product.

^†† Note:  BePharm's product B146899 and Synergy Scientific's product SynS146899 are the free acid form of this product.