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[Phorbol 12-Phenylacetate 13-Acetate 20-Homovanillate]
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Size |
US $ |
€ |
£ |
¥ |
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1 mg |
38 |
32 |
21 |
4600 |
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5 mg |
162 |
134 |
89 |
19400 |
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| US Dollars ($) | European Union Euros (€) | British Pounds (£) | Japanese Yen (¥) |
M.W. 688.76
C39H44O11
[175796-50-6]
WARNING: May be irritant to skin and mucous membranes. SPECIAL HAZARD: possible tumor promoter. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol. Disposal: A
View the MSDS for this product
Novel vanilloid (capsaicin) receptor ligand with dramatically different pharmacological properties relative to previously known vanilloids. Like capsaicin and resiniferatoxin, PPAHV binds to the vanilloid receptor (with slightly higher affinity than capsaicin), downregulates rat spinal cord vanilloid receptor number and desensitizes against neurogenic inflammation. However, this compound is inactive in inducing hypothermia (no effect seen at doses 200-fold higher than an active capsaicin dose) and ear edema in mice and is at least 100-fold weaker than capsaicin in terms of pungency in the eye-wiping assay. PPAHV also reduced or abolished the positive cooperativity of resiniferatoxin binding to rat spinal cord membranes. These unprecedented properties establish PPAHV as a useful new tool for investigating vanilloid receptor function in vitro and in vivo. Appendino, G., Cravotto, G., Palmisano, G., Annunziata, R., and Szallasi, A. "Synthesis and evaluation of phorboid 20-homovanillates: discovery of a class of ligands binding to the vanilloid (capsaicin) receptor with different degrees of cooperativity." J. Med. Chem. 39: 3123-3131 (1996). Szallasi, A., Acs, G., Cravotto, G., Blumberg, P.M., Lundberg, J.M., and Appendino, G. "A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor." Eur. J. Pharm. 299: 221-228 (1996).
Please inquire for bulk quantities of PPAHV at substantial discounts.
Pharmaceutical formulations containing this compound, and anti-inflammatory, anti-viral and anti-psoriatic uses, are covered by U.S. patents 5,643,948 and 5,955,501.
Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.
