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P-4227 Phorbol 13-Acetate, >99%

[Phorbol 13-Monoacetate]

M.W. 406.47

C22H30O7

[32752-29-7]

Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO or ethanol.  Disposal:  A

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• Reference compound for studying 12-deacylation of PMA.

• Phorbol 13-Acetate (P13A) mimics the effects of PMA on mouse ear erythema and in many in vitro assays.  However, the potency of P13A for these effects is very low, in the range of >100 µM.  As a consequence, some researchers, accustomed to observing biological responses to PMA at concentration of 1 nM to 1 µM, have erred in stating that P13A is inactive as a PKC activator, for example, see J. Pharmacol. Exp. Ther. 251:  634-639 (1989).  In fact, it is merely a lot less potent than PMA.

• Used to obtain the first X-ray crystal structure of a ligand bound to a PKC-derived cysteine-rich phorbol ester binding site.  Zhang, G., et al.  "Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester."  Cell 81:  917-924 (1995).

• Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.