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[2'-Amino-3'-methoxyflavone]
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Size |
US $ |
€ |
£ |
¥ |
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|
5 mg |
27 |
22 |
15 |
3200 |
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10 mg |
48 |
40 |
26 |
5800 |
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25 mg |
105 |
87 |
58 |
12600 |
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50 mg |
190 |
158 |
105 |
22800 |
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100 mg |
345 |
286 |
190 |
41400 |
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| Compare Quality and Prices LC Labs vs. Other Suppliers | |||
|---|---|---|---|
| US Dollars ($) | European Union Euros (€) | British Pounds (£) | Japanese Yen (¥) |
M.W. 267.28
C16H13NO3
[167869-21-8]
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Appearance: Pale-yellow powder Disposal: A
View the MSDS for this product
Potent, selective and cell-permeable inhibitor of MAP kinase kinase (also known as MAPK/ERK kinase or MEK kinase). Inhibits phosphorylation of MAP kinase by MAP kinase kinase. PD 98059 does not inhibit MAP kinase itself. IC50 values for PD 98059-induced effects are in the 1-20 µM range for many assays; it is somewhat weaker in inhibiting cell growth in monolayers or agar for some cell lines. Dudley, D.T., et al. "A synthetic inhibitor of the mitogen-activated protein kinase cascade." "Proc. Natl. Acad. Sci. USA 92: 7686-7689 (1995). Pang, L., et al. "Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor." J. Biol. Chem. 270: 13585-13588 (1995). Waters, S.B., et al. "Desensitization of Ras activation by a feedback disassociation of the SOS-Grb2 complex." J. Biol. Chem. 270: 20883-20886 (1995). Langlois, W.J., et al. "Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation." J. Biol. Chem. 270: 25320-25323 (1995). Alessi, D.R., et al. "PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo." J. Biol. Chem. 270: 27489-27494 (1995).
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