Home	Quick Product Lists	Contact LC Labs	Login/Register	My Account	View Cart
In Business 32 Years - Since 1980		THE CURRENT TIME at LC Labs is:
		Search:  Product Pages Only  Entire Site

L-4899 Lapatinib, Free Base, >99%

[GSK 572016] [GW-572016] [GW 572016X] [Tykerb] [Tyverb] [GSK-572016] [GSK572016] [GW572016]

M.W. 581.06

C29H26ClFN4O4S

[231277-92-2]

M.I. 14:  5367

Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO at 200 mg/mL; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.  Disposal:  A

Find and View a Certificate of Analysis for this product

View the MSDS for this product

• This is the free base form of lapatinib; please see our product Lapatinib, Di-p-Toluenesulfonate Salt, Cat. No. L-4804, for further technical information.  The di-p-toluenesulfonate salt form of lapatinib, not the free base, is used in the lapatinib formulation for use in humans.

• Lapatinib (as the di-p-toluenesulfonate salt) is the active ingredient in the drug sold under the trade names Tykerb® in the US and Tyverb® in Europe.  This drug has been approved in at least one country to treat advanced metastatic breast cancer in conjunction with the chemotherapy drug Xeloda (generic name, capecitabine).

• The CAS number for Lapatinib, Free Base is given above.  The CAS number of the di-p-toluenesulfonate salt (Cat. No. L-4804) is 388082-77-7.

• Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.

• This product is offered for R&D use in accordance with (i) 35 USC 271(e)+A13(1) in the U.S.; (ii) Section 69.1 of Japanese Patent Law in Japan; (iii) Section 11, No. 2 of the German Patent Act of 1981 in Germany; (iv) Section 60, Paragraph 5b of the U.K. Patents Act of 1977 in the U.K.; (v) Sections 55.2(1) and 55.2(6) and other common law exemptions of Canadian patent law; (vi) Section 68B of the Patents Act of 1953 in New Zealand together with the amendment of same by the Statutes Amendment Bill of 2002; (vii) such related legislation and/or case law as may be or become applicable in the aforementioned countries; and (viii) such similar laws and rules as may apply in various other countries.

• Not available in some countries; not available to some institutions; not available for some uses.