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THE CURRENT TIME at LC Labs is: |
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Size |
US $ |
€ |
£ |
¥ |
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5 mg |
79 |
66 |
43 |
9500 |
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10 mg |
138 |
115 |
76 |
16600 |
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25 mg |
275 |
228 |
151 |
33000 |
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M.W. 747.08
C41H70O9•Ca
[56092-82-1]
RTECS: NO0650000
Warning: Toxic.
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A
View the MSDS for this product
Antibiotic that acts as a potent and selective calcium ionophore; more effective than A23187. Ionomycin binds Ca2+ in the 7.0-9.5 pH range with the resulting complex exhibiting intense UV absorption. Liu, C. and Hermann T.E. "Characterization of ionomycin as a calcium ionophore." J. Biol. Chem. 253: 5892-5894 (1978). Kauffman, R.F., et al. "Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria." J. Biol. Chem. 255: 2735-2739 (1980).
Ionomycin induces apoptosis in immature B cell lines, for example, in Burkitt lymphoma cells, and in cultured embryonic rat cortical neurons. More mature B cell lines do not undergo apoptosis, but are arrested in the G1 phase of the cell cycle. Takei, N. and Endo, Y. "Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons." Brain Res. 652: 65-70 (1994). Aagaard-Tillery, K.M., et al. "Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis." J. Immunol. 155: 3297-3307 (1995).
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