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[PEP005] [3-Ingenyl Angelate] [Ingenyl 3-Angelate] [3-Angeloyl Ingenol] [3-Angelyl Ingenol]
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Size |
US $ |
€ |
£ |
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1 mg |
119 |
99 |
65 |
14300 |
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M.W. 430.54
C25H34O6
SPECIAL HAZARD: TUMOR PROMOTER. Gloves and mask should be worn when using this compound. Care must be taken to prevent contact through all routes of exposure.
Storage: Store at or below 4 ºC. Solubility: Soluble in DMSO or ethanol. Disposal: A
View the MSDS for this product
Protein Kinase C activator; anti-cancer drug. Hampson, P., et al. "PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC." Blood 106: 1362-1368 (2005). Kedei, N., et al. "Characterization of the interaction of ingenol 3-angelate with protein kinase C." Cancer Res. 64: 3243-3255 (2004).
Treatment with acids or bases or heating may cause rearrangement of the angeloyl group to the 5- or 20-positions leading to a significant decrease in potency.
Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.
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