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H-5239 H-89, Dihydrochloride Salt, >99%

[N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide, Di-HCl Salt] [H89] [H 89]

M.W. 519.29

C20H20BrN3O2S•2HCl

[127243-85-0]

Storage:  Store desiccated at or below -20 ºC.  Solubility:  Soluble in DMSO, water (up to 25 mg/mL; heat to dissolve), or ethanol/water.  Disposal:  A

View the MSDS for this product

• Potent and selective inhibitor of PKA, with an IC50 of about 50 nM.  Chijiwa, T., et al.  "Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells."  J. Biol. Chem. 265:  5267-5272 (1990).

• Also inhibits PKG and the µ isotype of PKC (at about 500 nM).  In contrast, most other PKC isotypes are much more weakly inhibited, with IC50's in the 32 µM range.  Johannes, F.-J., Prestle, J., Dieterich, S., Oberhagemann, P., Link, G. and Pfizenmaier, K.  "Characterization of activators and inhibitors of protein kinase Cµ." Eur. J. Biochem. 227:  303-307 (1995).

• Please request Technical Note #24 for additional information.

• Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.