In Business 32 Years - Since 1980
THE CURRENT TIME at LC Labs is:
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In Business 32 Years - Since 1980 |
THE CURRENT TIME at LC Labs is: |
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[N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinoline sulfonamide, Di-HCl Salt]
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Size |
US $ |
€ |
£ |
¥ |
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10 mg |
57 |
43 |
36 |
4400 |
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25 mg |
119 |
90 |
75 |
9100 |
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100 mg |
399 |
303 |
252 |
30600 |
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300 mg |
975 |
741 |
616 |
74700 |
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Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
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M.W. 519.28
C20H20BrN3O2S•2HCl
[127243-85-0]
Storage: Store desiccated at or below -20 ºC. Solubility: Soluble in DMSO, water (up to 25 mg/mL; heat to dissolve), or ethanol/water. Disposal: A
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View the MSDS for this product
Potent and selective inhibitor of PKA, with an IC50 of about 50 nM. Chijiwa, T., et al. "Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells." J. Biol. Chem. 265: 5267-5272 (1990).
Also inhibits PKG and the µ isotype of PKC (at about 500 nM). In contrast, most other PKC isotypes are much more weakly inhibited, with IC50's in the 32 µM range. Johannes, F.-J., Prestle, J., Dieterich, S., Oberhagemann, P., Link, G. and Pfizenmaier, K. "Characterization of activators and inhibitors of protein kinase Cµ." Eur. J. Biochem. 227: 303-307 (1995).
Please request Technical Note #24 for additional information.
Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
Our products are for laboratory research only and are sold only to qualified research institutions, not to individuals or patients nor for veterinary use.
