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G-6203 Gö 6976, >99%

[PD 406976] [Go 6976] [Gö6976] [Go6976] [Gö-6976] [Go-6976]

M.W. 378.43

C24H18N4O

[136194-77-9]

Storage:  Store at or below -20 ºC.  Solubility:  Soluble in DMSO.  Appearance:  Off-white to yellow solid.  Disposal:  A

View the MSDS for this product

• Novel, very potent PKC inhibitor with high selectivity for the A-group of PKC isotypes (α, β, and γ), with IC50 values in the 2-10 nM range.  Little or no inhibition of the B- and C-groups of PKC isotypes, even at much higher concentrations.  Kleinschroth, J., Hartenstein, J., Rudolph, C. and Schächtele, C.  "Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C."   Bioorg. Med. Chem. Lett. 3:  1959-1964 (1993).  Martiny-Baron, G., Kazanietz, M.G., Mischak, H., Blumberg, P., Kochs, G., Hug, H., Marme, D. and Schächtele, C.  "Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976."  J. Biol. Chem. 268:  9194-9197 (1993).

• Our Gö 6976 product contains less than 0.5% of the "wrong" isomer (in which the methyl and cyanoethyl groups are reversed).

• IMPORTANT:  we have recently found that Gö 6976 from several other vendors contains as much as 10% of the wrong isomer.  This is a serious problem because the incorrect isomer may inhibit kinases that Gö 6976 does not inhibit, thus leading to incorrect interpretations regarding the role of PKCα, β, and γ in cells or tissues being tested.  We are working to define the scope of this problem and to determine the kinase inhibitory profile of the wrong isomer.  (This entry last updated May 7, 2007).

• Please request Technical Note #2 for additional information about the nomenclature of PKC isotypes.

• Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.