In Business 32 Years - Since 1980
THE CURRENT TIME at LC Labs is:
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In Business 32 Years - Since 1980 |
THE CURRENT TIME at LC Labs is: |
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[Colforsin]
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Size |
US $ |
€ |
£ |
¥ |
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|
50 mg |
77 |
58 |
49 |
5900 |
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|
100 mg |
132 |
100 |
83 |
10100 |
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300 mg |
325 |
247 |
205 |
24900 |
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1 g |
660 |
501 |
417 |
50600 |
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3 g |
1560 |
1185 |
986 |
119600 |
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Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
| Compare Prices and Purity — LC Labs vs. Other Suppliers |
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M.W. 410.50
C22H34O7
[66575-29-9]
M.I. 12: 2539
M.I. 14: 2476
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO (5 mg/ml) or ethanol (6 mg/ml). Disposal: A
Find and View a Certificate of Analysis for this product
View the MSDS for this product
Forskolin is a naturally occurring diterpene from the Indian plant, Coleus forskohlii, that works as an activator of adenylate cyclase resulting in an increase in the intracellular concentration of cAMP. Laurenza, A., et al. "Forskolin: a specific stimulator of adenylyl cyclase or a diterpene with multiple sites of action?" Trends Pharm. Sci. 10: 442-447 (1989). Barber, R. and Goka, T.J. "Adenylate cyclase activity as a function of forskolin concentration." J. Cyclic Nucleotide Protein Phosphor. Res. 10: 23-29 (1985).
Forskolin acts as a smooth muscle relaxant and vasodilator in a concentration-dependent manner that affects both cytoplasmic calcium levels and contractile element calcium sensitivity. Abe, A. and Karaki, H.J. "Effect of forskolin on cytosolic Ca++ level and contraction in vascular smooth muscle." J. Pharmacol. Exp. Ther. 249: 895-900 (1989).
Forskolin is an inhibitor of mammalian glucose transporters and of a bacterial galactose-H+ transporter, GalP. Joost, H.G. and Steinfelder, H.J. "Forskolin inhibits insulin-stimulated glucose transport in rat adipose cells by a direct interaction with the glucose transporter." Mol. Pharmacol. 31: 279 (1987). Martin, G.E., et al. "Forskolin specifically inhibits the bacterial galactose-H+ transport protein, GalP." J. Biol. Chem. 269: 24870-24877 (1994).
Forskolin blocks PKC-activated ERK1 and ERK2 tyrosine phosphorylation and inhibits PKC-stimulated MAPK and Raf-1 activities in mouse bone-forming cells (MC3T3-E1 osteoblasts). Siddhanti, S.R., et al. "Forskolin inhibits protein kinase C-induced mitogen activated protein kinase activity in MC3T3-E1 osteoblasts." Endocrinology. 136: 4834-4841 (1995).
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Our products are for laboratory research only and are sold only to qualified research institutions, not to individuals or patients nor for veterinary use.
