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[17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin Hydrochloride] [NSC-707545] [Alvespimycin]
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Size |
US $ |
€ |
£ |
¥ |
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25 mg |
98 |
81 |
54 |
11800 |
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100 mg |
229 |
190 |
126 |
27500 |
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250 mg |
445 |
369 |
245 |
53400 |
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1 g |
988 |
820 |
543 |
118600 |
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2 g |
1760 |
1461 |
968 |
211200 |
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| US Dollars ($) | European Union Euros (€) | British Pounds (£) | Japanese Yen (¥) |
M.W. 653.22
C32H48N4O8•HCl
[150270-08-9]
Warning: Toxic.
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO; soluble up to about 2 mg/mL in water. Disposal: A
View the MSDS for this product
Synthetic derivative of geldanamycin, Cat. No. G-4500, and water-soluble analog of 17-AAG, Cat. No. A-6880, demonstrating stability and low in vivo toxicity similar to 17-AAG, but undergoes limited metabolism compared to 17-AAG. Egorin, M.J., et al. "Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats." Cancer Chemother. Pharmacol. 49: 7-19 (2002).
Binds specifically to heat shock protein Hsp90 in a manner similar to geldanamycin. Tian, Z.Q., et al. "Synthesis and biological activities of novel 17-aminogeldanamycin derivatives." Bioorg. Med. Chem. 12: 5317-5329 (2004).
Inhibits angiogenesis. Kaur, G, et al. "Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator." Clin. Cancer Res. 10: 4813-4821 (2004).
Enhances the radiation-induced cell cycle arrest of human solid tumor cell lines both in vitro and in vivo. Bull, E.E., et al. "Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin." Clin. Cancer Res. 10: 8077-8084 (2004).
Exhibits potent anti-tumor activity against MDA-MB-231 breast carcinoma cells and HL60-TB leukemia cells both of which are relatively insensitive to 17-AAG. Hollingshead, M., et al. "In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative." Cancer Chemother. Pharmacol. 56: 115-125 (2005).
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