In Business 32 Years - Since 1980
THE CURRENT TIME at LC Labs is:
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In Business 32 Years - Since 1980 |
THE CURRENT TIME at LC Labs is: |
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[Cyclosporine] [Antibiotic S 7481F1] [Ciclosporin A] [Ramihyphin A] [CsA]
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Size |
US $ |
€ |
£ |
¥ |
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1 g |
48 |
36 |
30 |
3700 |
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5 g |
165 |
125 |
104 |
12600 |
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10 g |
295 |
224 |
186 |
22600 |
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25 g |
575 |
437 |
363 |
44100 |
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100 g |
1100 |
836 |
695 |
84300 |
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Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
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M.W. 1202.61
C62H111N11O12
[59865-13-3]
M.I. 12: 2821
M.I. 14: 2752
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; soluble in ethanol at 200 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-10 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A
Find and View a Certificate of Analysis for this product
View the MSDS for this product
Cyclic hydrophobic oligopeptide isolated from the filamentous fungi, Tolypocladium inflatum, with potent immunosuppressant properties. Induces apoptosis in rat thymocytes and in murine B cell lymphoma cells, but prevents apoptosis in BLB cell lines induced by anti-IgM and ionomycin. Donjerkovic, D., et al. "Regulation of p27Kip1 accumulation in murine B-lymphoma cells: role of c-Myc and calcium." Cell. Growth Differ. 10: 695-704 (1999). Mordvinov, V.A., et al. "A human T-cell line with inducible production of interleukins 5 and 4. A model for studies of gene expression." J. Immunol. Methods 228: 163-168 (1999). Zaidan, E., et al. "Cyclosporin A-sensitive changes in mitochondrial glutathione are an early response to intrastiatal NMDA or forebrain ischemia in rats." J. Neurochem. 73: 2214-2217 (1999). Gottschalk, A.R., et al. "Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2." Proc. Natl. Acad. Sci. USA 91: 7350-7354 (1994).
The complex of cyclosporin A with the protein cyclophilin inhibits T-cell receptor signal transduction pathway via the inhibition of calcineurin (protein phosphatase 2B) with nanomolar affinity (Ki = 270 nM). Etzkorn, F.A., Chang, Z.Y., Stolz, L.A., Walsh, C.T. "Cyclophilin residues that affect noncompetitive inhibition of the protein serine phosphatase activity of calcineurin by the cyclophilin-cyclosporin A complex." Biochemistry 33: 2380-2388 (1994). Liu, J. "FK506 and ciclosporin: molecular probes for studying intracellular signal transduction." Trends Pharmacol. Sci. 14: 182-188 (1993).
Inhibits interleukin-1α-, lipopolysaccharide-, and TNF-α-nitric oxide synthesis induction. Fast, D.J., et al. "Cyclosporin A inhibits nitric oxide production by L929 cells in response to tumor necrosis factor and interferon-gamma." J. Interferon Res. 13: 235-240 (1993). Marumo, T., et al. "Cyclosporin A inhibits nitric oxide synthase induction in vascular smooth muscle cells." Hypertension 25: 764-768 (1995). Hattori, Y., and Naranishi, N. "Effects of cyclosporin A and FK506 on nitric oxide and tetrahydrobiopterin synthesis in bacterial lipopolysaccharide-treated J774 macrophages." Cell Immunol. 165: 7-11 (1995).
Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
Please see also our other standard immunosuppressant products:
Our products are for laboratory research only and are sold only to qualified research institutions, not to individuals or patients nor for veterinary use.
