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[Ro 32-0432] [BIM XI]
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Size |
US $ |
€ |
£ |
¥ |
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1 mg |
38 |
32 |
21 |
4600 |
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5 mg |
129 |
107 |
71 |
15500 |
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M.W. 489.02
C28H28N4O2•HCl
[151342-35-7]
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A
View the MSDS for this product
Orally active, potent and selective inhibitor of PKC; IC50 = 21 nM for rat brain PKC. Slightly less potent for the inhibition of PKCε (IC50 = 108 nM) than for the group A PKCs (IC50 = 9-37 nM). Wilkinson, S.E., et al. "Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C." Biochem. J. 294: 335-337 (1993). (Please request Technical Note #2.)
Other kinases are inhibited at much higher concentrations, e.g., PKA (IC50 = 8.6 µM), phosphorylase kinase (IC50 = 1.1 µM) and myosin light chain kinase (IC50 = 17.8 µM). Bit, R.A., et al. "Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction." J. Med. Chem. 36: 21-29 (1993).
See the product description for Bisindolylmaleimide I, Cat. No. B-2464, for a cautionary note regarding the effects of ATP concentrations on apparent inhibitory potencies.
Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.
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