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[Decumbin] [Ascotoxin] [Cyanein] [Nectrolide] [Synergisidin] [BFA]
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Size |
US $ |
€ |
£ |
¥ |
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10 mg |
45 |
37 |
25 |
5400 |
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25 mg |
99 |
82 |
54 |
11900 |
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50 mg |
165 |
137 |
91 |
19800 |
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100 mg |
295 |
245 |
162 |
35400 |
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300 mg |
698 |
579 |
384 |
83800 |
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M.W. 280.36
C16H24O4
[20350-15-6]
RTECS: GY8410000M.I. 11: 1363
M.I. 14: 1369
Warning: Toxic.
Storage: Store at or below -20 ºC in the dark. Solubility: Soluble in DMSO or ethanol. Disposal: A
View the MSDS for this product
Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus. Misumi, Y., et al. "Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes." J. Biol. Chem. 261: 11398-11403 (1986).
Brefeldin A has been shown to induce apoptosis in human tumor cells via a process requiring caspase activation. Guo, H., et al. "Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2." Exp. Cell Res. 245: 57-68 (1998).
Brefeldin A has been identified as an activator of the sphingomyelin signal transduction cycle. Linardic, C. M., et al. "Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking." Cell Growth Differ. 7: 765-774 (1996). Alessenko, A.V. "The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death." Membr. Cell Biol. 13: 303-320 (2000).
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