In Business 32 Years - Since 1980
THE CURRENT TIME at LC Labs is:
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In Business 32 Years - Since 1980 |
THE CURRENT TIME at LC Labs is: |
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[Decumbin] [Ascotoxin] [Cyanein] [Nectrolide] [Synergisidin] [BFA]
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Size |
US $ |
€ |
£ |
¥ |
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|
10 mg |
45 |
34 |
28 |
3400 |
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|
25 mg |
99 |
75 |
63 |
7600 |
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50 mg |
165 |
125 |
104 |
12600 |
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100 mg |
295 |
224 |
186 |
22600 |
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300 mg |
698 |
530 |
441 |
53500 |
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1 g |
1650 |
1254 |
1043 |
126500 |
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Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
| Compare Prices and Purity — LC Labs vs. Other Suppliers |
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M.W. 280.36
C16H24O4
[20350-15-6]
RTECS: GY8410000M.I. 11: 1363
M.I. 14: 1369
Warning: Toxic.
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO at 100 mg/mL; soluble in ethanol at 25 mg/mL with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 50-100 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility. Disposal: A
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View the MSDS for this product
Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum to the Golgi apparatus. Misumi, Y., et al. "Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes." J. Biol. Chem. 261: 11398-11403 (1986).
Brefeldin A has been shown to induce apoptosis in human tumor cells via a process requiring caspase activation. Guo, H., et al. "Brefeldin A-mediated apoptosis requires the activation of caspases and is inhibited by Bcl-2." Exp. Cell Res. 245: 57-68 (1998).
Brefeldin A has been identified as an activator of the sphingomyelin signal transduction cycle. Linardic, C. M., et al. "Activation of the sphingomyelin cycle by brefeldin A: effects of brefeldin A on differentiation and implications for a role for ceramide in regulation of protein trafficking." Cell Growth Differ. 7: 765-774 (1996). Alessenko, A.V. "The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death." Membr. Cell Biol. 13: 303-320 (2000).
Sold for laboratory or manufacturing purposes only; not for human, medical, veterinary, food, or household use.
Our products are for laboratory research only and are sold only to qualified research institutions, not to individuals or patients nor for veterinary use.
