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[Ro 31-8425] [BIM X]
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Size |
US $ |
€ |
£ |
¥ |
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1 mg |
38 |
32 |
21 |
4600 |
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5 mg |
129 |
107 |
71 |
15500 |
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M.W. 460.96
C26H24N4O2•HCl
[131848-97-0]
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO. Disposal: A
View the MSDS for this product
Potent inhibitor of PKC; IC50 = 15 nM against rat brain PKC. IC50's for the inhibition of the group A PKCs range from 8-13 nM and that for PKCε = 39 nM. Wilkinson, S.E., et al. "Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C." Biochem. J. 294: 335-337 (1993). (Please request Technical Note #2 for additional information on PKC nomenclature.)
Other kinases are inhibited at much higher concentrations, e.g., PKA (IC50 = 2.8 µM), phosphorylase kinase (IC50 = 1.3 µM) and myosin light chain kinase (IC50 = 3.7 µM). Bit, R.A., et al. "Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction." J. Med. Chem. 36: 21-29 (1993).
See the product description for Bisindolylmaleimide I, Cat. No. B-2464, for a cautionary note regarding the effects of ATP concentrations on apparent inhibitory potencies.
Sold for laboratory or manufacturing purposes only; not for human, veterinary, food, or household use.
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