In Business 32 Years - Since 1980
THE CURRENT TIME at LC Labs is:
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In Business 32 Years - Since 1980 |
THE CURRENT TIME at LC Labs is: |
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[B705008K112]
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Size |
US $ |
€ |
£ |
¥ |
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10 µg |
61 |
46 |
39 |
4700 |
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25 µg |
118 |
90 |
75 |
9000 |
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100 µg |
298 |
226 |
188 |
22800 |
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300 µg |
720 |
547 |
455 |
55200 |
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1 mg |
2190 |
1664 |
1384 |
167900 |
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Note: Our Euro, Pound, and Yen prices are revised regularly to account for currency exchange rate fluctuations.
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M.W. 905.03
C47H68O17
[83314-01-6]
M.I. 13: 1442
M.I. 14: 1457
Note: Binds to glass and plastic surfaces in aqueous solutions.
Storage: Store at or below -20 ºC. Solubility: Soluble in DMSO or ethanol. Disposal: A
Find and View a Certificate of Analysis for this product
View the MSDS for this product
Bryostatin 1 binds to and activates protein kinase C, but its biological effects differ greatly from those induced by other protein kinase C activators. Bryostatin 1 fails to mimic many effects caused by PMA and actually blocks some PMA-induced response in a variety of cells and tissues. Kraft, A.S., et al. "Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60." Proc. Natl. Acad. Sci. USA 83: 1334-1338 (1986). Sako, T., et al. "Partial parallelism and partial blockade by bryostatin 1 of effects of phorbol ester tumor promoters on primary mouse epidermal cells." Cancer Res. 47: 5445-5450 (1987). Dell'Aquila, M.L., et al. "Inhibition by bryostatin 1 of the phorbol ester-induced blockage of differentiation in hexamethylene bisacetamide-treated Friend erythroleukemia cells." Cancer Res. 47: 6006-6009 (1987). Hess, A.D., et al. "Activation of human T lymphocytes by bryostatin." J. Immunol. 141: 3263-3269 (1988).
The true affinity of bryostatin 1 for PDBu binding site on PKC appears to be in the low picomolar range or lower. de Vries, D.J., et al. "Demonstration of sub-nanomolar affinity of bryostatin 1 for the phorbol ester receptor in rat brain." Biochem. Pharmacol. 37: 4069-4073 (1988).
See technical Note #1 for additonal information.
Please note: The correct molecular weight for bryostatin I is 905.04. Perhaps the M.W. 887 error found in other catalogs arises because the original publication describing bryostatin I mentions a mass spectrum peak at 887, but apparently that peak resulted from the loss of one water molecule during the mass spectral process.
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Our products are for laboratory research only and are sold only to qualified research institutions, not to individuals or patients nor for veterinary use.
