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In Business 32 Years - Since 1980

THE CURRENT TIME at LC Labs is:  

1. IDENTIFICATION OF SUBSTANCE:
Trade name: Wortmannin
Product Number: W-2990
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420

2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: Wortmannin
Synonyms: KY 12420
Hazardous Ingredient: Wortmannin
CAS Registry Number: 19545-26-7
Molecular Weight: 428.43
Molecular Formula: C₂₃H₂₄O₈

3. HAZARDS IDENTIFICATION:
Hazard Description: Highly Toxic
This material is considered hazardous by the OSHA Hazard Communication Standard (29 CFR 1910.1200)
MAY BE FATAL IF ABSORBED THROUGH SKIN OR IF SWALLOWED
Do not ingest; do not get in eyes or on skin or clothing; wash thoroughly after handling
May be an irritant; may cause irritation to eyes, skin, and mucous membranes
Information pertaining to particular dangers for man and environment:
HMIS Ratings: Health =4 Flammability =0 Reactivity =0

4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration; call a physician
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: may emit toxic fumes under fire conditions

6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline powder
Color: white to off-white or light yellow
Odor:
Melting point/Melting range: not determined
Danger of explosion: none
Solubility in / Miscibility with water: very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content: none
Organic solvents: soluble in DMSO or ethanol

10. STABILITY AND REACTIVITY::
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide

11. TOXICOLOGICAL INFORMATION:
RTECS #: CB9641000
Acute toxicity: i.p. toxicity (LD50): 18 mg/kg (mouse)
Primary irritant effect:
On the skin: may be fatal if absorbed through skin; may be an irritant
On the eye: not known; may be an irritant
Inhalation: may be fatal if inhaled; may be irritating to mucous membranes and upper respiratory tract
Ingestion: may be fatal if swallowed.

12. ECOLOGICAL INFORMATION:
General notes: no data available

13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state and local regulations

14. TRANSPORT INFORMATION:
UN number: 2811
DOT:
Proper shipping name: Toxic solid, organic, n.o.s. (Wortmannin)
Hazard Class: 6.1
Packing group: II
IATA class:
Proper shipping name: Toxic solid, organic, n.o.s. (Wortmannin)
Hazard Class: 6.1
Packing group: II

15. REGULATIONS:
Code letter and hazard designation of product:
T+: Highly toxic
EU Risk And Safety phrases:
S22: Do not breathe dust
S36/37/39: Wear suitable protective clothing, gloves, and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
R26/27/28: Very toxic by inhalation, in contact with skin and if swallowed

16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability for any damage resulting from use of this material.