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In Business 32 Years - Since 1980

THE CURRENT TIME at LC Labs is:  

1. IDENTIFICATION OF SUBSTANCE:
Trade name: Pemetrexed, Disodium Salt, Heptahydrate
Product Number: P-7177
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420

2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid Disodium Heptahydrate
Synonyms: Alimta, LY-231514, MTA, Rolazar, Tifolar
Hazardous Ingredient: Pemetrexed, Disodium Salt, Heptahydrate
CAS Registry Number: 357166-29-1
Molecular Weight: 597.48
Molecular Formula: C₂₀H₁₉N₅Na₂O₆•7H₂O

3. HAZARDS IDENTIFICATION:
Hazard Description: Toxic if swallowed or inhaled
Prolonged exposure may result in serious damage to health
May be harmful to unborn child
Exposure may cause adverse blood effects including suppression of bone marrow function, thrombocytopenia (low platelet count), neutropenia (low white blood cell count), and anemia
Exposure may also impair liver function and cause reproductive tissue changes
Vitamin B12 and Folic Acid have been shown to reduce Pemetrexed toxicity
Exposure may cause irritation to eyes, mucous membranes, upper respiratory tract, and skin

4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.

6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid; granular or powder
Color: white to off-white
Odor: none
Melting point/Melting range: not determined
Danger of explosion: none
Solubility in / Miscibility with water: soluble in water at 100 mg/mL; buffers, serum, or other additives may increase or decrease the aqueous solubility
Solvent content:
Organic solvents: very poorly soluble in DMSO; very poorly soluble in ethanol

10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide and carbon dioxide, and nitrogen oxides

11. TOXICOLOGICAL INFORMATION:
RTECS No: not available
Acute toxicity: intravenous toxicity (LD50): 1332 mg/kg (male rat); >1574 mg/kg (female rat)
Primary irritant effect:
On the skin: irritant
On the eye: mild irritant
Inhalation: may be an irritant; may be toxic if inhaled
Ingestion: toxic if swallowed

12. ECOLOGICAL INFORMATION:
General notes: practically non-toxic to fish, aquatic invertebrates, and green algae

13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state and local regulations

14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be non-hazardous for transport

15. REGULATIONS:
Code letter and hazard designation of product:
T: Toxic
Xi: Irritant
EU Risk And Safety phrases:
S22: Do not breathe dust
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
S53: Avoid exposure-obtain special instructions before use
R36/38: Irritating to eyes and skin
R40: Possible risks of irreversible effects
R60: May impair fertility
R61: May cause harm to the unborn child

16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability for any damage resulting from use of this material.