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In Business 29 Years - Since 1980

THE CURRENT TIME at LC Labs is:  

1. IDENTIFICATION OF SUBSTANCE:
Trade name: Oxaliplatin
Product Number: O-7111
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
1-781-937-0777 Fax: 1-781-938-5420

2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: Oxalato(1R,2R-cyclohexanediamine)platinum(II)
Synonyms: Foloxatine, Transplatin, Eloxatin, Eloxatine, Elplat, RP 54780, NSC-266046, NSC-271670, Dacplat, Oxalatoplatin, Oxalatoplatinum, D01790
Hazardous Ingredient: Oxaliplatin
CAS Registry Number: 61825-94-3
Molecular Weight: 397.29
Molecular Formula: C₈H₁₄N₂O₄Pt

3. HAZARDS IDENTIFICATION:
Hazard Description: Harmful if inhaled, swallowed, or absorbed through the skin
Harmful to unborn child
Exposure may cause irritation of the respiratory tract, eye, and skin and allergic respiratory and skin reaction
Ingestion may result in damage to the kidneys, reproductive system, liver, bone marrow, ears (hearing loss), peripheral nervous system, and gastrointestinal system

4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
After eye contact: check for and remove contact lenses; flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician

5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder, or foam
Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Unusual fire hazard: may emit toxic fumes under fire conditions such as carbon monoxide, etc.

6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol; dispose of contaminated material according to Section 13

7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes, and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC

8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles

9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: solid powder
Color: white to off-white
Odor: none
Melting point/Melting range: not tested
Danger of explosion: none
Solubility in / Miscibility with water: soluble in water at 4 mg/mL
Solvent content: none
Organic solvents: soluble in DMSO at 20 mg/mL; very slightly soluble in methanol; insoluble in ethanol

10. STABILITY AND REACTIVITY:
Stability: stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be avoided: protect from light and heat
Dangerous products of decomposition: thermal decomposition may produce toxic gases such as carbon monoxide, carbon dioxide, and nitrogen oxides

11. TOXICOLOGICAL INFORMATION:
RTECS No: TP2275850
Acute toxicity: oral toxicity (LD50): 14.3 mg/kg (rat)
Primary irritant effect:
On the skin: mild to severe skin irritation; hazardous in case of skin contact
On the eye: mild to severe eye irritation; hazardous in case of eye contact
Inhalation: hazardous if inhaled; causes respiratory tract irritation
Ingestion: hazardous if swallowed; may result in fetal harm or death

12. ECOLOGICAL INFORMATION:
General notes: no data available

13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state and local regulations

14. TRANSPORT INFORMATION:
UN number: 2811
DOT:
Proper shipping name: Toxic solid, organic, n.o.s. (Oxaliplatin)
Hazard Class: 6.1
Packing group: II
IATA class:
Proper shipping name: Toxic solid, organic, n.o.s. (Oxaliplatin)
Hazard Class: 6.1
Packing group: II

15. REGULATIONS:
Code letter and hazard designation of product:
T: Toxic
EU Risk And Safety phrases:
S22: Do not breathe dust
S36/37: Wear suitable protective clothing and gloves
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible)
S53: Avoid exposure - obtain special instructions before use
R/23/24/25: Toxic by inhalation, in contact with skin, and if swallowed
R36/37/38: Irritating to eyes, respiratory system and skin
R40: Limited evidence of a carcinogenic effect
R42/43: May cause sensitization by inhalation and skin contact
R60: May impair fertility
R61: May cause harm to the unborn child
R64: May cause harm to breastfed babies
R68: Possible risk of irreversible effects

16. OTHER INFORMATION:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel. The burden of safe use of this material rests entirely with the user. LC Laboratories disclaims all liability for any damage resulting from use of this material.