1. IDENTIFICATION OF SUBSTANCE:
Trade name: Leptomycin B
Product Number: L-6100
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420
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2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-
[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-
hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid
Synonyms: LMB, Elactocin, CI-940, CL-1957A, NSC-364372,
PD-114720
Hazardous Ingredient: Leptomycin B
CAS Registry Number: 87081-35-4
Molecular Weight: 540.74
Molecular Formula: C33H48O6
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3. HAZARDS IDENTIFICATION:
RTECS substance category (refers to ethanol): Tumorigen,
Mutagen, Reproductive Effector, Primary Irritant
Exposure may
cause irritation to eyes, mucous membranes upper respiratory
tract and skin
Exposure may also cause the following; effect
fertility and/or newborn and breastfed infants; general
anaesthtic, coma,
hallucinations and distorted perceptions;
arrythmias; nausea or vomitting
HMIS Ratings: Health =1 Flammability =0 Reactivity =0
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4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing
is difficult, give oxygen; if breathing stops, give artificial
respiration
After skin contact: flush with copious amounts of water;
remove contaminated clothing and shoes; call a physician
After eye contact: flush with copious amounts of water;
assure adequate flushing by separating the eyelids with
fingers; call a physician
After swallowing: if swallowed, wash out mouth with copious
amounts of water; call a physician
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5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide,
dry chemical powder or foam
Protective equipment: wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and
eyes.
Unusual fire hazard: may emit toxic fumes under fire
conditions
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6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill;
wear self-contained breathing apparatus, protective clothing
and heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with
finely-powdered liquid-binding material (diatomite, universal
binders); decontaminate surfaces and equipment by scrubbing
with alcohol; dispose of contaminated material according to
Section 13
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7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes
and clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC
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8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
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9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: film
Color: clear
Odor:
Melting point/Melting range:
Danger of explosion: none
Solubility in / Miscibility with water: not soluble
Solvent content: none
Organic solvents: soluble in ethanol and methanol
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10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from
light and heat
Dangerous products of decomposition: thermal decomposition
may produce toxic gases such as carbon monoxide and carbon
dioxide
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11. TOXICOLOGICAL INFORMATION:
To the best of our knowledge, the chemical, physical and
toxicological properties have not been fully investigated
Only selected Registry of Toxic Effects of Chemical Substances
(RTECS) data is presented above
See actual entry in RTECS for
complete information
RTECS No: 64-17-5 (Ethanol)
Target Organs: Eyes; Respiratory system; Skin; CNS; Circulatory
system; Reproductive system
Toxicity Data: (Data refers to ethanol): RAT-ORL LD50:
7060mg/kg;
RAT-IPR LD50: 3600ug/kg; RAT-IVN LD50: 1440mg/kg;
RAT-IAT LD50: 11mg/kg; MUS-ORL LD50: 3450mg/kg;
IPR-MUS LD50: 528mg/kg; SCU-MUS LD50: 1973mg/kg;
MUS-IVN LD50: 1973mg/kg
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12. ECOLOGICAL INFORMATION:
General notes: no data available
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13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal,
state and local regulations
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14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be
non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be
non-hazardous for transport
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15. REGULATIONS:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:
S7: Keep container tightly closed
S9: Keep container in a well ventilated place
S16:Keep away from sources of ignition - no smoking
S24/25: Avoid contact with skin and eyes
S36/37/39: Wear suitable protective clothing, gloves, and
eye/face protection
S45: In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible)
R11: Highly flammable
R20/21/22:Harmful by inhilation, in contact with skin and
if swallowed
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16. OTHER INFORMATION:
The above information is believed to be correct based on
our present knowledge but does not purport to be
complete. For research use only by trained personnel. The
burden of safe use of this material rests entirely with
the user. LC Laboratories disclaims all
liability for any damage resulting from use of this
material. |
