1. IDENTIFICATION OF SUBSTANCE:
Trade name: FK-506
Product Number: F-4900
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420
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2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name: FK-506
Synonyms: Tacrolimus, Prograf
Hazardous Ingredient: FK-506
CAS Registry Number: 104987-11-3
Molecular Weight: 804.03
Molecular Formula: C44H69NO12
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3. HAZARDS IDENTIFICATION:
Hazard Description: potent immunosuppresent;
may cause irritation to eyes, skin, mucous membranes
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4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to
fresh air; if breathing is difficult, give oxygen; if
breathing stops, give artificial respiration
After skin contact: flush with copious
amounts of water; remove contaminated clothing and shoes;
call a physician
After eye contact: check for and remove conact lenses and
flush with copious amounts of water; assure adequate flushing
by separating the eyelids with fingers; call a physician
After swallowing: if swallowed, wash out
mouth with copious amounts of water; call a physician
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5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water
spray, carbon dioxide, dry chemical powder or foam
Protective equipment: wear
self-contained breathing apparatus and protective
clothing to prevent contact with skin and eyes.
Unusual fire hazard: none known
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6. ACCIDENTAL RELEASE MEASURES:
Person-related safety
precautions: cordon off area of spill; wear
self-contained breathing apparatus, protective clothing
and heavy rubber gloves
Measures for cleaning/collecting: absorb
solutions with finely-powdered liquid-binding material
(diatomite, universal binders); decontaminate surfaces
and equipment by scrubbing with alcohol; dispose of
contaminated material according to Section 13
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7. HANDLING AND STORAGE:
Information for safe handling: avoid inhalation and
contact with skin, eyes, and clothing; material may be an
irritant
Storage: store solid and solutions at
-20 ºC
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8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal
protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved
respirator
Protection of hands: chemical-resistant rubber
gloves
Eye protection: chemical safety goggles
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9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: solid powder
Color: white to off-white
Odor: none
Melting point/Melting range: not available
Danger of explosion: none
Solubility in / Miscibility with water:
not soluble
Solvent content: none
Organic solvents: soluble in DMSO or
methanol
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10. STABILITY AND REACTIVITY:
Stability:
stable if stored as directed; avoid strong oxidizing agents
Thermal decomposition / conditions to be
avoided: protect from light and heat
Dangerous products of decomposition:
thermal decomposition may produce toxic gases such as
carbon monoxide, carbon dioxide, and nitrogen oxides
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11. TOXICOLOGICAL INFORMATION:
RTECS#: KD4200000
Acute toxicity:
none known
Primary irritant effect:
On the skin: may be harmful
On the eye: may be an
irritant
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12. ECOLOGICAL INFORMATION:
General notes: no data available
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13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country,
federal, state and local regulations
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14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this
substance is considered to be non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this
substance is considered to be non-hazardous for transport
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15. REGULATIONS:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
Risk phrases: may be irritating to eyes,
skin and respiratory system
Safety phrases: in case of accident,
flush eyes or skin with copious amounts of water; remove
contaminated clothing and shoes; call a physician
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16. OTHER INFORMATION:
The above information is believed to be correct based on
our present knowledge but does not purport to be
complete. For research use only by trained personnel. The
burden of safe use of this material rests entirely with
the user. LC Laboratories disclaims all
liability for any damage resulting from use of this material.
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