1. IDENTIFICATION OF SUBSTANCE:
Trade name: Fasudil, Monohydrochloride Salt
Product Number: F-4660
Manufacturer/Supplier:
LC Laboratories
165 New Boston Street
Woburn, MA 01801 USA
+1-781-937-0777 Fax: +1-781-938-5420
|
2. COMPOSITION/DATA ON COMPONENTS:
Chemical Name:
1-(5-Isoquinolinesulfonyl)homopiperazine Monohydrochloride
Synonyms: HA-1077
Monohydrochloride; Eril; AT-877
Hazardous Ingredient: HA-1077, Monohydrochloride Salt
CAS Registry Number: 105628-07-7
Molecular Weight: 327.84
Molecular Formula: C14H17N3O2S•HCl
|
3. HAZARDS IDENTIFICATION:
Hazard Description:
May be an irritant; exposure may cause irritation to eyes, skin, mucous
membranes, and upper respiratory tract
Information pertaining to
particular dangers for man and environment:
HMIS Ratings: Health =1 Flammability =0 Reactivity =0
|
4. FIRST AID MEASURES:
After Inhalation: If inhaled, remove to fresh air; if breathing is
difficult, give oxygen; if breathing stops, give artificial
respiration
After skin contact: flush with copious amounts of water; remove
contaminated clothing and shoes; call a physician
After eye contact: flush with copious amounts of water; assure
adequate flushing by separating the eyelids with fingers; call a
physician
After swallowing: if swallowed, wash out mouth with copious
amounts of water; call a physician
|
5. FIRE FIGHTING MEASURES:
Suitable extinguishing agents: water spray, carbon dioxide, dry
chemical powder or foam
Protective equipment: wear self-contained breathing apparatus
and protective clothing to prevent contact with skin and
eyes.
Unusual fire hazard: may emit toxic fumes under fire
conditions
|
6. ACCIDENTAL RELEASE MEASURES:
Person-related safety precautions: cordon off area of spill; wear
self-contained breathing apparatus, protective clothing and
heavy rubber gloves
Measures for cleaning/collecting: absorb solutions with finely-
powdered liquid-binding material (diatomite, universal binders);
decontaminate surfaces and equipment by scrubbing with
alcohol; dispose of contaminated material according to Section
13
|
7. HANDLING AND STORAGE:
Information for safe handling: avoid contact with skin, eyes and
clothing; material may be an irritant
Storage: store solid and solutions at -20 ºC
|
8. EXPOSURE CONTROLS AND PERSONAL PROTECTION:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator
Protection of hands: chemical-resistant rubber gloves
Eye protection: chemical safety goggles
|
9. PHYSICAL AND CHEMICAL PROPERTIES:
Form: crystalline solid
Color: white
Odor: none
Melting point/Melting range:
Danger of explosion: none
Solubility in / Miscibility with water: very soluble in water, up to
about 200 mg/mL
Solvent content: none
Organic solvents: soluble in DMSO up to about 95 mg/mL; not
soluble in ethanol
|
10. STABILITY AND REACTIVITY:
Stability: avoid acids and bases
Thermal decomposition / conditions to be avoided: protect from
light and heat
Dangerous products of decomposition: thermal decomposition
may produce toxic gases such as carbon monoxide and carbon
dioxide
|
11. TOXICOLOGICAL INFORMATION:
Acute toxicity: none known
Primary irritant effect:
On the skin: none known
On the eye: not known; may be an irritant
|
12. ECOLOGICAL INFORMATION:
General notes: no data available
|
13. DISPOSAL CONSIDERATION:
Dispose of in accordance with prevailing country, federal, state
and local regulations
|
14. TRANSPORT INFORMATION:
DOT:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be
non-hazardous for transport
IATA class:
Proper shipping name: none
Non-Hazardous for transport: this substance is considered to be
non-hazardous for transport
|
15. REGULATIONS:
Code letter and hazard designation of product:
Hazard-determining components of labeling:
EU Risk And Safety phrases:
S22: Do not breathe dust
S24/25: Avoid contact with skin and eyes
S36/37/39: Wear suitable protective clothing, gloves, and
eye/face protection
R20/21/22: Harmful by inhalation, in contact with skin and if
swallowed
|
16. OTHER INFORMATION:
The above information is believed to be correct based on
our present knowledge but does not purport to be
complete. For research use only by trained personnel. The
burden of safe use of this material rests entirely with
the user. LC Laboratories disclaims all liability
for any damage resulting from use of this material. |
